252049-12-0 Usage
Uses
Used in Biochemical Research:
FMOC-D-LYS(NICOTINOYL)-OH is used as a peptide synthesis compound for the protection and synthesis of peptides. Its FMOC group provides a protective mechanism, ensuring the correct formation of peptide bonds during the synthesis process.
Used in Pharmaceutical Development:
FMOC-D-LYS(NICOTINOYL)-OH is used as a building block in the design and synthesis of novel pharmaceutical compounds. The presence of the nicotinoyl group, which is related to niacin, may offer potential benefits in the development of drugs targeting various health conditions, given the importance of niacin in human metabolism and its role in certain therapeutic applications.
Used in Academic Research:
FMOC-D-LYS(NICOTINOYL)-OH is used as a research tool in academic institutions, where scientists explore its properties and potential applications in various fields, such as molecular biology, biochemistry, and medicinal chemistry. FMOC-D-LYS(NICOTINOYL)-OH's unique structure allows for the investigation of its interactions with other molecules and its potential role in biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 252049-12-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,2,0,4 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 252049-12:
(8*2)+(7*5)+(6*2)+(5*0)+(4*4)+(3*9)+(2*1)+(1*2)=110
110 % 10 = 0
So 252049-12-0 is a valid CAS Registry Number.
252049-12-0Relevant articles and documents
Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
Huhtiniemi, Tero,Suuronen, Tiina,Lahtela-Kakkonen, Maija,Bruijn, Tanja,J??skel?inen, Sanna,Poso, Antti,Salminen, Antero,Lepp?nen, Jukka,Jarho, Elina
supporting information; experimental part, p. 5616 - 5625 (2010/09/14)
Sirtuins catalyze the NAD+ dependent deacetylation of N ε-acetyl lysine residues to nicotinamide, O′-acetyl-ADP- ribose (OAADPR) and Nε-deacetylated lysine. Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the screening of novel Nε-modified lysine containing inhibitors against SIRT1 and SIRT2. Nε-Selenoacetyl and N ε-isothiovaleryl were the most potent moieties found in this study, comparable to the widely studied Nε-thioacetyl group. The Nε-3,3-dimethylacryl and Nε-isovaleryl moieties gave significant inhibition in comparison to the Nε-acetyl group present in the substrates. In addition, the studied Nε- alkanoyl, Nε-α,β-unsaturated carbonyl and N ε-aroyl moieties showed that the acetyl binding pocket can accept rather large groups, but is sensitive to even small changes in electronic and steric properties of the Nε-modification. These results are applicable for further screening of Nε-acetyl analogues.
