252049-72-2

Basic information

• Product Name: (2S)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-(R)-mandelamide
• Synonyms: (2S)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-(R)-mandelamide
• CAS NO: 252049-72-2
• Molecular Weight: 313.397
• Mol File: 252049-72-2.mol

Chemical Properties

• CAS DataBase Reference: (2S)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-(R)-mandelamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-(R)-mandelamide(252049-72-2)
• EPA Substance Registry System: (2S)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-(R)-mandelamide(252049-72-2)

Safety Data

• Hazardous Substances Data: 252049-72-2(Hazardous Substances Data)

Upstream product

• 68164-74-9 1-(2,6-Dimethylphenoxy)-2-methansulfonyloxy-propan 
• 252049-70-0 (2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide 
• 72806-53-2 1-(2,6-Dimethylphenoxy)-2-azido-propan 
• 61102-09-8 (RS)-1-(2,6-dimethylphenoxy)propan-2-ol 
• 31828-71-4 RS-mexiletine 
• 576-26-1 2.6-dimethylphenol 

Downstream Products

• 94991-72-7 (S)-mexiletine 

Relevant articles and documents

Preparation of highly enantiopure stereoisomers of 1-(2,6-dimethylphenoxy)-2-aminopropane (mexiletine)

Mexiletine [1-(2,6-dimethylphenoxy)-2-aminopropane], an orally effective antiarrhythmic agent, exhibits enantioselective pharmacokinetics and pharmacodynamics during mexiletine therapy. The purpose of this paper is to emphasize the advantage of tetrahydropyranyl-protected mandelic acid (THPMA) in the resolution of mexiletine enantiomers. Both enantiomers of mexiletine were obtained in 99% enantiomeric excess. Judging by the differential shielding effects in the 1H and 13C NMR analyses, we have observed the opposite predominant conformation for the mexiletine mandelates in comparison with the O-methylmandelates.