25205-92-9

Upstream product

• 3424-93-9 4-methoxyphenylacetamide 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 1140505-17-4 2-(4-methoxyphenyl)-4-phenyl-5-((trimethylsilyl)methyl)oxazole 
• 591-50-4 iodobenzene 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 29548-91-2 1-phenyl-1,1-difluoropropan-2-one 
• 29548-92-3 1,1-difluoro-1-phenylpropan-2-ol 
• 874-90-8 4-methoxybenzonitrile 
• 536-45-8 sodium anisate 

Downstream Products

• 92560-98-0 2-Methyl-2-[4-(5-methyl-4-phenyl-oxazol-2-yl)-phenoxy]-propionic acid ethyl ester 
• 92560-96-8 4-(5-Methyl-4-phenyl-oxazol-2-yl)-phenol 
• 92561-04-1 2-Methyl-2-[4-(5-methyl-4-phenyl-oxazol-2-yl)-phenoxy]-propionic acid 
• 92560-97-9 [4-(5-Methyl-4-phenyl-oxazol-2-yl)-phenoxy]-acetic acid ethyl ester 
• 92561-03-0 [4-(5-Methyl-4-phenyl-oxazol-2-yl)-phenoxy]-acetic acid 

Relevant academic research and scientific papers

Efficient one-pot synthesis of substituted oxazoles from 3-trimethylsilylpropargylic alcohols and amides by gold-catalyzed substitution followed by cycloisomerization

3-Trimethylsilylpropargylic alcohols 1, on treatment with amides 2 in the presence of catalytic amounts of cationic gold(III), underwent propargylic substitution followed by cycloisomerization, in which the key feature is the -cation-stabilizing effect of

Lewis acid-mediated defluorinative [3+2] cycloaddition/aromatization cascade of 2,2-difluoroethanol systems with nitriles

The properties of C?F bonds, including high thermal and chemical stability, make derivatization of organic fluorine-containing compounds by the activation of the C?F bond and subsequent functionalization quite challenging. We herein report a Lewis acid-mediated defluorinative cycloaddition/aromatization cascade of 2,2-difluoroethanols with nitriles as a novel synthetic method for the preparation of 2,4,5-trisubstituted oxazoles. This reaction, which involves cleavage of two C?F bonds and the consecutive formation of C?O and C?N bonds in a one-pot fashion, features a broad substrate scope and moderate to high reaction yields. Mechanistic studies revealed that the reaction is initiated by the Lewis acid-mediated ring closure of the 2,2-difluoroethanol to produce the fluoroepoxide intermediate. (Figure presented.).

Synthesis of 2,4- and 2,4,5-substituted oxazoles via a silver triflate mediated cyclization

2,4- and 2,4,5-substituted oxazoles were prepared from a broad range of bromo-ketones and amides in high yield and purity.

Potential Hypolipidemic Agents: Part III - Synthesis and Hypolipidemic Activity of 4-(4,5-Substituted oxazol-2-yl)phenoxyalkanoic Acid Derivatives

A number of 4-(4,5-substituted oxazol-2-yl)phenoxyalkanoic acid derivatives have been synthesised and evaluated for their hypolipidemic activity.Ethyl 4-(4-p-chlorphenyl-5-methyloxazol-2-yl)phenoxyacetate (3) exhibits significant hypocholesterolemic and h