2521-84-8

Basic information

• Product Name: L-CYCLOPENTYL GLYCINE
• Synonyms: (S)-AMINO-CYCLOPENTYL-ACETIC ACID;(S)-2-AMINO-2-CYCLOPENTYL ACETIC ACID;H-GLY(CYCLOPENTYL)-OH;H-L-CYCPENTGLY-OH;L-BETA-CYCLOPENTYLGLYCINE;L-CYCLOPENTYL GLYCINE;(2S)-AMINO(CYCLOPENTYL)ETHANOIC ACID;L-CYCLOPENTYLGLYCINE 98%
• CAS NO: 2521-84-8
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• EINECS: 200-258-5
• Product Categories: Amino acids, non natural;Chiral Compounds;pharmacetical;Peptide;a-amino;Non-natural amino acids
• Mol File: 2521-84-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 276.6 °C at 760 mmHg
• Flash Point: 121.1 °C
• Appearance: /
• Density: 1.167 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Store at 0°C
• PKA: 2.49±0.10(Predicted)
• CAS DataBase Reference: L-CYCLOPENTYL GLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: L-CYCLOPENTYL GLYCINE(2521-84-8)
• EPA Substance Registry System: L-CYCLOPENTYL GLYCINE(2521-84-8)

Safety Data

• Hazardous Substances Data: 2521-84-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2521-84-8 differently. You can refer to the following data:
1. L-Cyclopentylglycine is used in the preparation and resolution of cyclopentaneglycine.
2. 2-Cyclopentyl-L-glycine is used in the preparation and resolution of cyclopentaneglycine.

InChI:InChI=1/C5H9NO2/c7-5(8)3-6-4-1-2-4/h4,6H,1-3H2,(H,7,8)

Upstream product

• 112741-63-6 (3S,5S,6R)-3-Cyclopent-2-enyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester 
• 933-95-9 cyclopentylglycine 
• 936448-97-4 2-((Benzyloxycarbonyl)amino)-2-(2-cyclopentenyl)-N-methoxyacetamide 
• 14579-08-9 3-trimethylsilylcyclopent-1-ene 
• 1556-18-9 cyclopentyl iodide 
• 546141-10-0 benzyl (2R,3S,5S)-(-)-6-oxo-2,3-diphenyl-5-cyclopentyl-4-morpholinecarboxylate 
• 145275-92-9 2-Amino-2-cyclopentyl-N-methoxyacetamide 
• 2521-83-7 2-acetamido-2-cyclopentylacetic acid 

Downstream Products

• 801162-35-6 cyclopentylglycine methyl ester 
• 1426836-51-2 C₄₅H₅₈N₈O₆Si 
• 14328-66-6 N-Tosyl-S-benzyl-cysteinyl-tyrosyl-(2-cyclopentyl-2-amino-essigsaeuremethylester) 
• 109183-72-4 (S)-2-((tert-butoxycarbonyl)amino)-2-cyclopentylacetic acid 

Relevant articles and documents

SYNTHESIS METHOD FOR L-CYCLIC ALKYL AMINO ACID AND PHARMACEUTICAL COMPOSITION HAVING THEREOF

A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD+, and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is where n1≧1, m1≧0 and the M1 is H or a monovalent cation; the Structural Formula (II) is where n2≧0, m2≧0, the M2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.

Deracemisation and stereoinversion of alpha-amino acids using D-amino acid oxidase and hydride reducing agents.

The deracemisation and stereoinversion of both cyclic and acyclic DL-alpha-amino acids, using porcine kidney D-amino acid oxidase (DAAO) and a hydride reducing agent (NaCNBH3-NaBH4), has been investigated.

Practical Asymmetric Syntheses of α-Amino Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine Templates

The optically active D- and L-erythro-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) and D- and L-erythro-4-(tert-butoxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) can be efficiently brominated to serve as electrophilic glycine templates for the asymmetric synthesis of amino acids.It was found that coupling to these templates can proceed with either net retention or net inversion of stereochemistry.The final deblocking to the amino acids is accomplished with either dissolving-metal reduction or catalytic hydrogenolysis.The syntheses of β-ethyl aspartic acid, norvaline, allylglycine, alanine, norleucine, homophenylalanine, p-methoxyhomophenylalanine, cyclopentylglycine, and cyclopentenylglycine and a formal synthesis of clavalanine are described.In addition, the direct asymmetric syntheses of N-t-BOC-allylglycine and N-t-BOC-cyclopentenylglycine are described.