252209-36-2

Upstream product

• 252209-26-0 1R(1α,2β,3α,4α,5β)-3-acetoxy-4-benzyloxy-2-(O-benzylhydroxylamino)-1',5-(isopropylidenedioxy)-1-methyl-1-cyclopentanol 
• 252209-28-2 1R(1α,2β,3α,4α,5β)-2-amino-4-benzyloxy-1',5-(isopropylidenedioxy)-1-methyl-1,3-cyclopentanediol 
• 93173-26-3 2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl isothiocyanate 

Downstream Products

• 252209-37-3 C₅₁H₅₈N₂O₁₁ 
• 252209-38-4 C₅₁H₅₆N₂O₁₀ 

Relevant academic research and scientific papers

A concise and highly efficient synthesis of trehazolin and trehalamine starting from D-mannose

(formula presented) A concise synthesis of trehazolin, its aglycon, trehalamine, and a known analogue has been developed starting from D-mannose. This new approach features a very stereoselective and high-yielding ketone-oxime ether reductive carbocyclization promoted by samarium diiodide as a key step for the preparation of the aminocyclitol component and a mild and very efficient intramolecular triflate displacement reaction for the construction of the oxazoline ring.