252264-84-9

Basic information

• Product Name: tert-butyl N-methyl-N-(1-phenylethyl)carbamate
• Synonyms: tert-butyl N-methyl-N-(1-phenylethyl)carbamate
• CAS NO: 252264-84-9
• Molecular Weight: 235.326
• Mol File: 252264-84-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl N-methyl-N-(1-phenylethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-methyl-N-(1-phenylethyl)carbamate(252264-84-9)
• EPA Substance Registry System: tert-butyl N-methyl-N-(1-phenylethyl)carbamate(252264-84-9)

Safety Data

• Hazardous Substances Data: 252264-84-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6907-71-7 N-(1-phenylethylidene)methanamine 
• 81616-14-0 tert-butyl N-benzyl-N-methylcarbamate 
• 74-88-4 methyl iodide 
• 42882-26-8 N-methyl-N-(1-phenylethyl)amine 

Downstream Products

• 78491-88-0 2,2-dimethyl-4-phenylpentan-3-ol 

Relevant articles and documents

CHIRALITY SENSING WITH MOLECULAR CLICK CHEMISTRY PROBES

The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite.

Reactivity and Enantioselectivity in the Reactions of Scalemic Stereogenic α-(N-Carbamoyl)alkylcuprates

Stereogenic 2-(N-carbamoyl)pyrrolidinylcuprates prepared from scalemic (i.e., enantioenriched) N-Boc-2-lithiopyrrolidine and THF soluble CuCN·2LiCl react with vinyl iodides, vinyl triflates, β-iodo-α,β-enoates, propargyl mesylates, and allyl bromide to afford the substitution products with excellent enantioselectivity. Excellent enantiomeric ratios are obtained in the conjugate addition reactions with methyl vinyl ketone while low enantiomeric ratios can be achieved with acrylate esters using HMPA/TMSCl activation. Enantiomeric ratios vary with substrate substitution patterns and the observed enantioselectivities appear to be more a function of cuprate-electrophile reactivities than of the reaction type (e.g., substitution, conjugate addition). Low enantiomeric ratios are obtained with the α-(N-carbamoyl)benzylcuprates. The lithium-copper transmetalation and cuprate vinylation reactions proceed with retention of configuration.