252279-84-8

Basic information

• Product Name: (5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[(isoxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one
• Synonyms: (5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[(isoxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one
• CAS NO: 252279-84-8
• Molecular Weight: 362.361
• Mol File: 252279-84-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[(isoxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[(isoxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one(252279-84-8)
• EPA Substance Registry System: (5R)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[(isoxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one(252279-84-8)

Safety Data

• Hazardous Substances Data: 252279-84-8(Hazardous Substances Data)

Upstream product

• 154590-62-2 (R)-tert-butyl-4-(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)piperazine-1-carboxylate 
• 252279-83-7 tert-butyl 4-(2-fluoro-4-{(5R)-5-[(isoxazol-3-yloxy)methyl]-2-oxo-1,3-oxazolidin-3-yl}phenyl)piperazine-1-carboxylate 

Downstream Products

• 776296-77-6 C₂₂H₂₂FN₅O₇ 
• 887275-42-5 (4-{2-Fluoro-4-[(R)-5-(isoxazol-3-yloxymethyl)-2-oxo-oxazolidin-3-yl]-phenyl}-piperazin-1-yl)-acetonitrile 

Relevant articles and documents

Synthesis and biological activity of novel oxazolidinones

A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results.

Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position

Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.

OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS

The present invention relates to substituted phenyl oxazolidinones and processes for preparing thereof. This invention also relates to pharmaceutical compositions comprising compounds of the present invention. Such compounds can be useful antimicrobial ag