25229-97-4

Basic information

• Product Name: 2-Cyano-3-morpholinoacrylamide
• Synonyms: 2-CYANO-3-MORPHOLINOACRYLAMIDE;3-Morpholino-2-cyanoacrylamide;3-MORPHOLINE-2-CYANOACYLAMIDE;2-CYANO-3-MORPHOLINOACRYLAMIDE 98%;2-Cyano-3-morpholin-4-ylprop-2-enamide;2-Propenamide, 2-cyano-3-(4-morpholinyl)-;2-CYANO-3-MORPHOLINOACRYLAMIDE, 98%, PURE;2-Cyano-3-morpholinoacrylamide, pure
• CAS NO: 25229-97-4
• Molecular Formula: C₈H₁₁N₃O₂
• Molecular Weight: 181.19
• EINECS: 246-741-5
• Mol File: 25229-97-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 173-177 °C
• Boiling Point: 314.3°C (rough estimate)
• Flash Point: 193.4 °C
• Appearance: light yellow crystalline powder
• Density: 1.2444 (rough estimate)
• Vapor Pressure: 1.75E-06mmHg at 25°C
• Refractive Index: 1.7400 (estimate)
• PKA: 12.73±0.50(Predicted)
• CAS DataBase Reference: 2-Cyano-3-morpholinoacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-3-morpholinoacrylamide(25229-97-4)
• EPA Substance Registry System: 2-Cyano-3-morpholinoacrylamide(25229-97-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 25229-97-4(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

InChI:InChI=1/C8H11N3O2/c9-5-7(8(10)12)6-11-1-3-13-4-2-11/h6H,1-4H2,(H2,10,12)/b7-6-

Upstream product

• 110-91-8 morpholine 
• 122-51-0 orthoformic acid triethyl ester 
• 107-91-5 cyanoacetic acid amide 
• 22630-09-7 trimorpholylmethane 

Downstream Products

• 315-30-0 4-hydroxypyrazolo(3,4-d)pyrimidine 

Relevant articles and documents

Preparation method for hemisulphate

The invention provides a preparation method for hemisulphate, and relates to the technical field of organic synthesis. The method comprises the following steps: step 1, dissolving malonamide nitrile, triethyl orthoformate and morpholine in absolute ethyl alcohol, raising the temperature for refluxing, and cooling to 15-25 DEG C after the reaction is completed; step 2, separating out solids from a mixture obtained in step 1, centrifuging, washing with ethyl alcohol, recrystallizing by using ethyl alcohol refluxing, cooling to 15-25 DEG C, then centrifuging, washing with ethyl alcohol, and drying to obtain a pre-product A; step 3, adding the pre-product A into water, heating to 50-80 DEG C, dropwise adding hydrazine hydrate, raising the temperature to 100-115 DEG C, reacting under refluxing for 25-35 min, and cooling to 15-25 DEG C to obtain a pre-product B; step 4, adjusting the pH of the pre-product B to be acid, cooling to 15-25 DEG C to separate out solids, centrifuging, washing, heating the solids to 75-85 DEG C with water, adding activated carbon and stirring for 10-15 min, filtering, centrifuging, washing, and drying to obtain a product. The method provided by the invention has the beneficial effects that the reaction temperature and time are quantitatively controlled, and the recovery rate of the final product of hemisulphate reaches 85% or above.

Reaction of Ortho Esters with Secondary Amines

The scope of the reaction of ortho esters with secondary amines has been explored.With p-toluenesulfonic acid as catalyst, N-alkylanilines and orthoformates gave high yields of N-alkylformanilides and N,N-dialkylanilines in contrast to previous work with other acid catalysts where ortho amides were produced in low yield.Aliphatic cyclic amines (e.g., morpholine, piperidine) and orthoformates gave the corresponding ortho amides.This constitutes a new convenient synthesis of these useful reagents.