252305-03-6Relevant articles and documents
Design and synthesis of isoxazole containing bioisosteres of epibatidine as potent nicotinic acetylcholine receptor agonists
Singh, Satendra,Avor, Kwasi S.,Pouw, Buddy,Seale, Thomas W.,Basmadjian, Garo P.
, p. 1501 - 1505 (1999)
An efficient synthesis of isoxazole containing isosteres of epibatidine is described. The synthesis proceeded from N-tert-butoxycarbonyl (Boc)-exo-2- (methoxycarbonyl)-7-azabicyclo[2.2.1]heptane (9). Compound 9 was reacted with the dilithium salt of an ap