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Upstream product

• 87-91-2 diethyl (2R,3R)-tartrate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 608-68-4 dimethyl L-tartrate 
• 106-38-7 para-bromotoluene 

Relevant academic research and scientific papers

Highly Enantioselective Allylation of Ketones: An Efficient Approach to All Stereoisomers of Tertiary Homoallylic Alcohols

An optimized protecting group for allylboronates allowed the use of ketones in order to synthesize all isomers of quaternary homoallylic alcohols with high enantioselectivities. All symmetric isomers of the allylboronate were prepared in high yields and diastereoselectivities using Sn2′ reactions. The improved reactivity of the novel protecting group was verified by following the reaction kinetics with 1H NMR spectroscopy. Mechanistic studies using DFT calculations were conducted to investigate the new findings. Thus, the stereochemical outcome and enhanced reactivity can be rationalized.

Chiral 5,5,10,10-tetraaryl-bicyclo[4.4.0]-3,8-bisphosphate and preparation method and application thereof

The invention discloses chiral 5,5,10,10-tetraaryl-bicyclo[4.4.0]-3,8-bisphosphate, a preparation method of the 5,5,10,10-tetraaryl-bicyclo[4.4.0]-3,8-bisphosphate and application of the 5,5,10,10-tetraaryl-bicyclo[4.4.0]-3,8-bisphosphate. The structural formula of the chiral compound is as follows: shown in the description. The preparation method comprises the following steps of reacting optically pure tartaric ester with a Grignard reagent to obtain chiral 1,1,4,4-tetraaryl butantetraol; under the presence of organic alkali, performing high regioselective 1,3-cylcophosphorylation reaction on the chiral 1,1,4,4-tetraaryl butantetraol and phosphorus oxychloride at a temperature of 0 to 36 DEG C so as to obtain the chiral 5,5,10,10-tetraaryl-dicyclo[4.4.0]-3,8-diphosphonic acid. The chiral 5,5,10,10-tetraaryl-bicyclo[4.4.0]-3,8-bisphosphate has the advantage of excellent chiral induction capability, and can be used for catalyzing asymmetric synthesis. The method has the advantages of easiness in material obtainment, simplicity in technological process, simplicity in operation, good reaction selectivity and high product yield.

Optically active compounds

Optically active butane-1,2,3,4-tetraol derivatives of formula (I). The compounds may be used as doping agents for liquid crystals for a wide range of applications, such as solid state cholesteric filters for projection displays, circular polarizers, and optical filters.