252357-46-3

Upstream product

• 16640-68-9 cyanomethylene triphenylphosphorane 
• 252357-48-5 (+/-)-4-(N-benzyloxycarbonyl-amino)-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile 

Downstream Products

• 438202-60-9 {(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester 
• 252357-49-6 ((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butyl)-carbamic acid benzyl ester 
• 252357-51-0 C₃₈H₃₈F₂N₃O₄P 
• 252357-52-1 C₃₈H₃₈F₂N₃O₄P 
• 252357-54-3 Boc-Leu-6,6-difluoro-3-oxo-2-triphenylphosphoranylidene-hexanenitrile 
• 438202-62-1 4-((1S,2S)-1-{(S)-1-[3-Cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butylcarbamoyl}-2-methyl-butylcarbamoyloxymethyl)-benzoic acid methyl ester 
• 438202-56-3 (2S,3S)-2-Amino-3-methyl-pentanoic acid {(S)-1-[3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propylcarbamoyl]-3-methyl-butyl}-amide 
• 438202-43-8 4-{(1S,2S)-1-[(S)-1-((S)-3,3-Difluoro-1-oxalyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyloxymethyl}-benzoic acid methyl ester 
• 262437-60-5 (S)-2-Amino-4-methyl-pentanoic acid [3-cyano-1-(2,2-difluoro-ethyl)-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-amide 

Relevant academic research and scientific papers

Peptide inhibitors of hepatitis C virus NS3 protease

Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of the invention, optimized for binding in the S1 specificity p

Evolution, synthesis and SAR of tripeptide α-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease

N-Terminal truncation of the hexapeptide ketoacid 1 gave rise to potent tripeptide inhibitors of the hepatitis C virus NS3 protease/NS4A cofactor complex. Optimization of these tripeptides led to ketoacid 30 with an IC50 of 0.38 μM. The SAR of these tripeptides is discussed in the light of the recently published crystal structures of a ternary tripetide/NS3/NS4A complexes.