25245-37-8

Basic information

• Product Name: 1-iodo-2,3,4-trimethoxybenzene
• CAS NO: 25245-37-8
• Molecular Formula: C₉H₁₁IO₃
• Molecular Weight: 294.0863
• Mol File: 25245-37-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 304.8°C at 760 mmHg
• Flash Point: 138.2°C
• Density: 1.602g/cm³
• Vapor Pressure: 0.00154mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 1-iodo-2,3,4-trimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-iodo-2,3,4-trimethoxybenzene(25245-37-8)
• EPA Substance Registry System: 1-iodo-2,3,4-trimethoxybenzene(25245-37-8)

Safety Data

• Hazardous Substances Data: 25245-37-8(Hazardous Substances Data)

Usage

General Description

1-iodo-2,3,4-trimethoxybenzene, also known as 2,3,4-trimethoxy-iodobenzene, is a chemical compound that belongs to the group of iodobenzenes. It consists of a benzene ring with three methoxy groups and one iodine atom attached to it. It is commonly used in organic synthesis as a reagent for various chemical reactions, such as halogenation and nucleophilic substitution. 1-iodo-2,3,4-trimethoxybenzene has potential applications in pharmaceuticals, agrochemicals, and material science due to its versatile reactivity and ability to be incorporated into various molecular structures. Additionally, it is important to handle and store this compound with caution, as it is toxic and may cause irritation to the skin, eyes, and respiratory system if proper safety measures are not taken.

Upstream product

• 634-36-6 1,2,3-trimethoxybenzene 

Downstream Products

• 21450-56-6 1,2,3,4-tetramethoxybenzene 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 934-00-9 3-methocycatechol 
• 87-66-1 2-hydroxyresorcinol 
• 71953-00-9 (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester 
• 381222-47-5 (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(2',3',4'-trimethoxyphenyl)propionic acid tert-butyl ester 
• 501-65-5 diphenyl acetylene 
• 74882-21-6 1-(2,3,4-trimethoxyphenyl)butane 
• 859785-14-1 5-(2',3',4'-trimethoxyphenyl)pentanoic acid 
• 33257-15-7 1,2,3-trimethoxy-4-methylbenzene 
• 43020-38-8 2,3,4-trimethoxybenzonitrile 

Relevant articles and documents

Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo

Background: Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology,

Selective Claisen rearrangement and iodination for the synthesis of polyoxygenated allyl phenol derivatives

Allyl aryl ethers and allyl phenol derivatives were prepared starting from commercial or synthetized phenols. Either Williamson reaction or Et2AlCl catalyzed Claisen rearrangement was performed to obtain the polyoxygenated molecules. The pivotal allyl phenols were then modified by methylation, iodocyclization or electrophilic aromatic iodination to afford the polyoxygenated derivatives in good to excellent yields. Additionally, their antibacterial properties were also investigated against Gram-positive and Gram-negative bacteria.

Nitrogen dioxide-catalyzed electrophilic iodination of arenes

Nitrogen dioxide is demonstrated to be an effective catalyst precursor for the iodination of alkoxy-substituted benzenes and naphthalenes. Different from the transition metal catalysts, nitrogen dioxide can be easily separated from the final products, and is free of heavy metal waste. Although the present catalyst precursor is toxic, it does not stain the final products due to its low-boiling character. No other reagents apart from 0.5 equiv. of iodine (I 2), 6.5 mol% nitrogen dioxide and acetonitrile solvent were used in the iodination, and basically all the iodine atoms in the iodine source were transferred to the iodination products, showing that the presented protocol is highly atom-economic and practical. Copyright