252552-08-2Relevant academic research and scientific papers
8-Methyl-7-substituted-1,6-naphthyridine-3-carboxylic acids as new 6-desfluoroquinolone antibacterials
Sabatini, Stefano,Cecchetti, Violetta,Tabarrini, Oriana,Fravolini, Arnaldo
, p. 953 - 957 (1999)
1,6-Naphthyridine-8-methyl-7-substituted-3-carboxylic acids were synthesized as new 6-desfluoro-quinolone antibacterials in which the usual fluorine atom at C-6 position was replaced by an endocyclic nitrogen atom. Comparing the antibacterial activity of these 6-azaquinolones with our previous 6-amino and 6-hydrogen counterparts, they resulted always less active. However, the presence of methyl group at C-8 position ensure good Gram- positive antibacterial activity, with minimum inhibitory concentrations values on the same order of ciprofloxacin for piperidinyl derivative 3d and tetrahydroisoquinolinyl derivative 3c.
INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
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Page/Page column 66; 67, (2014/02/15)
Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
