252574-01-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyrrolidinamine, 4-methoxy-N-methyl, (3S,4S)-(9CI) is used as a chemical building block for the synthesis of various pharmaceuticals and bioactive molecules. Its unique structure and chirality make it a valuable component in the development of new drugs and therapeutic agents.
Used in Research and Development:
3-Pyrrolidinamine, 4-methoxy-N-methyl, (3S,4S)-(9CI) is used as a research compound in the field of organic chemistry and medicinal chemistry. It serves as a starting material or intermediate in the synthesis of complex organic molecules and can be used to study the properties and reactivity of secondary amines.
Used in Drug Discovery:
3-Pyrrolidinamine, 4-methoxy-N-methyl, (3S,4S)-(9CI) is used in drug discovery processes to identify potential lead compounds with therapeutic properties. Its unique structure and chirality can contribute to the development of novel drugs with improved efficacy and selectivity.

Upstream product

• 945483-46-5 (3S,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolidine 
• 945483-45-4 (3R,4S,αS)-N(1)-benzyl-3-methoxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolid-2-one 
• 906750-11-6 (3R,4S,αS)-N(1)-benzyl-3-hydroxy-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolid-2-one 
• 906750-10-5 (4R,αS)-N(1)-benzyl-4-[N'-methyl-N'-(α-methylbenzyl)amino]pyrrolid-2-one 
• 906750-09-2 methyl (3R,αS)-3-[N-methyl-N-(α-methylbenzyl)amino]-4-(N'-benzyl-N'-allylamino)butanoate 

Downstream Products

• 175414-77-4 vosaroxin 

Relevant academic research and scientific papers

Asymmetric synthesis of 3,4-anti- and 3,4-syn-substituted aminopyrrolidines via lithium amide conjugate addition

The diastereoselective conjugate addition of homochiral lithium amides to methyl 4-(N-allyl-N-benzylamino)but-2-enoate has been used as the key step in a simple and efficient protocol for the preparation of 3,4-substituted aminopyrrolidines. This protocol provides a complementary and stereoselective route to both anti- and syn-3-amino-4-alkylpyrrolidines as well as anti- and syn-3-hydroxy-4-aminopyrrolidines, in high de and ee via β-amino enolate functionalisation. This methodology has been applied to the synthesis of anti-(3S,4S)- and syn-(3R,4S)-3-methoxy-4-(N-methylamino)pyrrolidine. The Royal Society of Chemistry.

Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines

Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e. The Royal Society of Chemistry 2006.