252579-97-8

Upstream product

• 226949-82-2 (3S,5R)-5-butyl-3-phenyl-2,3,5,6-tetrahydrooxazolo[3,2-a]pyrimidin-7-one 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Enantioselective synthesis of α,β-substituted β-amino acids

Chiral derivative 3 was shown to be a precursor of α and β-substituted β-amino acids as well as α,β-disubstituted β-amino acids. The key steps of the procedure are a diastereoselective alkylation of synthon 3 by organocuprates reagents and a diastereoselective alkylation of the alkylated adduct.

Stereoselective α-alkylation of new chiral auxiliaries: An access to enantiomerically pure α- and α,β-substituted β-amino acids

New bicyclic heterocycles 5, which are potentially useful for the enantioselective synthesis of substituted β-amino acids, have been synthesized. A study on the α-alkylation of these chiral auxiliaries is presented. An optically pure β-amino acid was obtained in excellent yield from its masked chiral derivative 6a.