252579-98-9Relevant academic research and scientific papers
Enantioselective synthesis of α,β-substituted β-amino acids
Agami, Claude,Cheramy, Sandrine,Dechoux, Luc,Melaimi, Mohand
, p. 195 - 200 (2007/10/03)
Chiral derivative 3 was shown to be a precursor of α and β-substituted β-amino acids as well as α,β-disubstituted β-amino acids. The key steps of the procedure are a diastereoselective alkylation of synthon 3 by organocuprates reagents and a diastereoselective alkylation of the alkylated adduct.
Stereoselective α-alkylation of new chiral auxiliaries: An access to enantiomerically pure α- and α,β-substituted β-amino acids
Agami, Claude,Cheramy, Sandrine,Dechoux, Luc
, p. 1838 - 1840 (2007/10/03)
New bicyclic heterocycles 5, which are potentially useful for the enantioselective synthesis of substituted β-amino acids, have been synthesized. A study on the α-alkylation of these chiral auxiliaries is presented. An optically pure β-amino acid was obtained in excellent yield from its masked chiral derivative 6a.
