252580-10-2Relevant academic research and scientific papers
Ring-opening of oxazolines derived from l-serine: a short and efficient stereoselective synthesis of all four diastereomers of 3-mercaptoaspartic acid derivatives
Lee, Sang-Hyeup,Bok, Juhan,Qi, Xin,Kim, Sook Kyung,Lee, Yoon-Sik,Yoon, Juyoung
, p. 7309 - 7312 (2008/03/13)
Facile methods are described for accessing four diastereomerically pure 3-mercaptoaspartic acid derivative from l-aspartic acid. In our synthesis, ring-opening reactions of oxazoline-4,5-dicarboxylate with thiolacetic acid as well as the stereochemical interconversion of both α- and β-configuration via oxazoline chemistry were utilized as key steps.
A practical method for the synthesis of β-amino α-hydroxy acids. Synthesis of enantiomerically pure hydroxyaspartic acid and isoserine
Cardillo, Giuliana,Gentilucci, Luca,Tolomelli, Alessandra,Tomasini, Claudia
, p. 1727 - 1730 (2007/10/03)
The iodocyclization of 3-benzoylamino carboxylic acid derivatives gives oxazoline-5-carboxylates which are precursors of β-amino-α-hydroxy acids.
