252651-85-7

Basic information

• Product Name: Oxiranecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)- (9CI)
• Synonyms: Oxiranecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)- (9CI)
• CAS NO: 252651-85-7
• Molecular Formula: C8H14O3
• Molecular Weight: 158.19496
• Product Categories: CARBOXYLICESTER
• Mol File: 252651-85-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Oxiranecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Oxiranecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)- (9CI)(252651-85-7)
• EPA Substance Registry System: Oxiranecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)- (9CI)(252651-85-7)

Safety Data

• Hazardous Substances Data: 252651-85-7(Hazardous Substances Data)

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Relevant articles and documents

SYSTEMS AND METHODS FOR REGIOSELECTIVE CARBONYLATION OF 2,2-DISUBSTITUTED EPOXIDES

Provided are methods of carbonylating cyclic substrates to produce carbonyl ated cyclic products. The cyclic substrates may be 2, 2-di substituted epoxides and the cyclic products may be β,β-di substituted lactones. The method may be carried out by forming and pressurizing a reaction mixture of the cyclic substrate, a solvent, carbon monoxide, and a [LA+][CO(CO)4-] catalyst, where [LA+] is a Lewis acid capable of coordinating to the cyclic substrate. The method may proceed with a regioselectivity of 90:10 or greater. The resulting carbonylated cyclic products may be converted to ketone aldol products that retain the stereochemistry and enantiomeric ratio of the carbonyl ated cyclic products.

BIARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS

The present invention relates to biaryl monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A1, Q, A2, M, W, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a biaryl monobactam compound of the invention or a pharmaceutically acceptable salt therof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.