252681-04-2

Basic information

• Product Name: (3S)-2,2-difluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-3-phenylpropanoic acid
• Synonyms: (3S)-2,2-difluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-3-phenylpropanoic acid
• CAS NO: 252681-04-2
• Molecular Weight: 321.324
• Mol File: 252681-04-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S)-2,2-difluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-2,2-difluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-3-phenylpropanoic acid(252681-04-2)
• EPA Substance Registry System: (3S)-2,2-difluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-3-phenylpropanoic acid(252681-04-2)

Safety Data

• Hazardous Substances Data: 252681-04-2(Hazardous Substances Data)

Upstream product

• 249920-08-9 2,4-diphenyl-1,3-oxazolidine 
• 252681-03-1 (4S)-3,3-difluoro-1-((1R)-2-hydroxy-1-phenylethyl)-4-phenylazetidin-2-one 

Downstream Products

• 667938-19-4 (2-{Benzyl-[(S)-2,2-difluoro-3-((R)-2-hydroxy-1-phenyl-ethylamino)-3-phenyl-propionyl]-amino}-2-phenyl-acetylamino)-acetic acid ethyl ester 

Relevant articles and documents

Synthesis of difluorinated pseudopeptides using chiral α,α- difluoro-β-amino acids in the Ugi reaction

2,2-Difluoro-3-(2-hydroxy-1 R-phenylethylamino)-3 S-phenylpropionic acid 3, obtained by a Reformatsky-type reaction of ethyl bromodifluoroacetate with (4R)-2,4-diphenyloxazolidine, was used as a classical carboxylic acid in the Ugi reaction to prepare various difluorinated pseudopeptides 5a-n. Compounds 5 were then deprotected by hydrogenolysis to furnish difluorinated pseudopeptides 6.