252756-53-9Relevant academic research and scientific papers
Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives
Tozkoparan, Birsen,Ertan, Mevluet,Kelicen, Pelin,Demirdamar, Ruemeysa
, p. 588 - 593 (1999)
Sixteen new 2-benzylidene-7-methyl-3-oxo-5-(substituted phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl esters (1a-4d) have been synthesized by reacting 1,2,3,4-tetrahydropyrimidine-2-thiones (1-4) with chloroacetic acid and appropriate benzaldehydes in a single step. Their structures have been proved by IR, 1H NMR, mass spectra and elemental analysis. The compounds were tested for their anti-inflammatory activities. Test results revealed that compounds 1b, 1c, 4a and 4c exerted moderate anti-inflammatory activity at the 100 mg/kg dose level compared with indomethacin. Copyright (C) 1999 Elsevier Science S.A.
