25278-95-9

Basic information

• Product Name: MELIANTRIOL
• Synonyms: MELIANTRIOL;(13α,14β,17α,20S,21R,23R,24S)-21,23-Epoxy-5α-lanost-7-ene-3β,21,24,25-tetrol
• CAS NO: 25278-95-9
• Molecular Formula: C30H50O5
• Molecular Weight: 490.715
• Mol File: 25278-95-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 620.6°Cat760mmHg
• Flash Point: 329.1°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 5.33E-18mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: MELIANTRIOL(CAS DataBase Reference)
• NIST Chemistry Reference: MELIANTRIOL(25278-95-9)
• EPA Substance Registry System: MELIANTRIOL(25278-95-9)

Safety Data

• Hazardous Substances Data: 25278-95-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C30H50O5/c1-26(2)22-9-8-20-19(28(22,5)13-12-23(26)31)11-15-29(6)18(10-14-30(20,29)7)17-16-21(35-25(17)33)24(32)27(3,4)34/h8,17-19,21-25,31-34H,9-16H2,1-7H3/t17-,18+,19-,21+,22?,23-,24-,25+,28+,29-,30+/m0/s1

Relevant articles and documents

Triterpenoids from the fruits of Azadirachta indica (Meliaceae)

Four new triterpenoids, indicalilacols A-D (1-4), were isolated from the MeOH extract of the fruits of Azadirachta indica, including a new 19(10 → 9β)abeo-tirucallane derivative, two new tirucallane-type triterpenoids, and a new euphane-type triterpenoid, along with three known tirucallane-type triterpenoids. Their structures were elucidated on the basis of spectroscopic analyses. The absolute configuration of 2 was elucidated by the chemical conversion of 2 into 21-oxo-melianodiol 24,25-acetonide. Compounds 2, 6-8 exhibited moderate cytotoxicity against three human cancer cell lines, including multidrug-resistant (MDR) cancer cells (KB-C2). Although compound 5 was not cytotoxic against any of the tested cancer cell lines, 5 showed cytotoxicity against KB-C2 cells in the presence of 2.5 μM colchicine, suggesting that 5 might have an MDR-reversal effect.