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25279-15-6

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25279-15-6 Usage

General Description

"(20S,24R)-12β,25-Dihydroxy-20,24-epoxydammarane-3-one" is a specific chemical compound. It belongs to the vast structures of triterpenoids coming from the dammarane family. This specific compound exhibits the stereoisomerism property, featuring two chiral centers (20S, 24R) in its structure. The naming further indicates its structure consisting of hydroxyl groups at positions 12 and 25. Additionally, it has an epoxy bond (containing an oxygen atom) between carbons 20 and 24, and a one carbonyl group at position 3. The precise bioactivity and applications of this specific dammarane derivative can vary, and are typically subject to research in the context of its source and potential uses.

Check Digit Verification of cas no

The CAS Registry Mumber 25279-15-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,2,7 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 25279-15:
(7*2)+(6*5)+(5*2)+(4*7)+(3*9)+(2*1)+(1*5)=116
116 % 10 = 6
So 25279-15-6 is a valid CAS Registry Number.

25279-15-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25279-15-6 SDS

25279-15-6Relevant articles and documents

Synthesis and Structure-Activity Relationship of Pyxinol Derivatives as Novel Anti-Inflammatory Agents

Bi, Wenjing,Cui, Yetong,Fan, Huaying,Fang, Xiaojuan,Gao, Hongyan,Gao, Meng,Sun, Yixiao,Tang, Hanhan,Wang, Conghui,Yang, Gangqiang,Yu, Hui,Zhang, Leiming

, p. 457 - 463 (2020)

Pyxinol, the main metabolite of 20S-protopanaxadiol in human liver, was chosen as a novel skeleton for the development of anti-inflammatory agents. Pyxinol derivatives modified at C-3, C-12, or C-25 and selected stereoisomers were designed, prepared, and investigated for in vitro anti-inflammatory activities. Structure-activity relationship (SAR), focused on skeleton, was analyzed based on their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis. The preliminary SAR results signified that the biological activity of the pyxinol derivatives is largely dependent on the R/S stereochemistry of pyxinol skeleton and the hydroxy at C-3 is a modifiable position. Among the tested compounds, the 3-oximinopyxinol (4a) exhibited the most potent NO-inhibitory activity and was even comparable to the steroid drug. Furthermore, compound 4a also significantly decreased LPS-induced TNF-α and IL-6 synthesis and iNOS and COX-2 expressions via the NF-κB pathway. This study proves that pyxinol is an interesting skeleton for anti-inflammatory drug discovery.

Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3β,12β,25-triol derivatives as α-glucosidase and PTP1B inhibitors

Chen, Ji-Jun,Geng, Chang-An,Li, Tian-Ze,Liu, Pei,Yang, Xiao-Tong

, p. 350 - 367 (2022/01/19)

The dammarane triterpenoid (20S,24R)-epoxy-dammarane-3β,12β,25-triol obtained from Cyclocarya paliurus in our previous study showed inhibitory activity on α-glucosidase in vitro with an inhibitory ratio of 32.2% at the concentration of 200 μM. In order to reveal the structure-activity relationships (SARs) and get more active compounds, 42 derivatives of (20S,24R)-epoxy-dammarane-3β,12β,25-triol were synthesized by chemical modification on the hydroxyls (C-3 and C-12), rings A and E, and assayed for their α-glucosidase and PTP1B inhibitory activities. Two compounds (8, 26) increased activity against α-glucosidase, and four compounds (8, 15, 26, 42) significantly inhibited PTP1B. It was noted that compounds 8 and 26 could inhibit both α-glucosidase and PTP1B as dual-target inhibitors with IC50 values of 489.8, 467.7 μM (α-glucosidase) and 319.7, 269.1 μM (PTP1B). Compound 26 was revealed to be a mix-type inhibitor on α-glucosidase and a noncompetitive-type inhibitor on PTP1B based on enzyme kinetic study. Furthermore, compound 42 could selectively inhibited PTP1B as a mix-type inhibitor with IC50 value of 134.9 μM, which was 2.5-fold higher than the positive control, suramin sodium (IC50 339.0 μM), but not inhibit α-glucosidase. [Figure not available: see fulltext.].

Ocotillol-type sapogenin derivatives with tumor drug resistance reversal activity and preparation method and application thereof

-

Paragraph 0044; 0049, (2019/01/08)

The invention relates to a kind of ocotillol-type sapogenin derivatives and medicine compounds containing the ocotillol-type sapogenin derivatives and preparation method and tumor drug resistance reversal application thereof. According to the ocotillol-type sapogenin derivatives, through a result obtained on a tumor drug resistance oral epidermoid carcinoma cell strain, the prepared ocotillol-typesapogenin derivatives have good drug resistance reversal activity separately, and are obviously better than ocotillol-type sapogenin; meanwhile, products have good gastrointestinal tract stability and good drug applicability, namely characteristics which compounds disclosed in the prior art do not have.

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