25284-12-2Relevant academic research and scientific papers
Three new ways to synthesize 1,3-azole derivatives by microwaves
Bougrin, Khalid,Loupy, Andre?,Soufiaoui, Mohamed
, p. 8055 - 8064 (1998)
Three new ways to synthesize 1,3-azoles derivatives on mineral supports using Ca(OCl)2/Al2O3 or MnO2/SiO2 or by fusion 'in dry media' are described. The reactions are activated under microwave irradia
Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
Yeon Kim, Bo,Hee Yoon, Ji,Kim, Myeongbin,Nyoung Kim, Jae,Park, Hwangseo,Eon Ryu, Seong,Lee, Sangku
supporting information, p. 1746 - 1748 (2019/05/21)
Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhi
KMnO4/HOAc system promoted one-pot synthesis of benzoxazoles from o-aminophenols or oxidative cyclization of o-hydroxyarylidene anilines at room temperature
Mirjalili,Bamoniri,Bagheri
, p. 809 - 814 (2016/04/05)
1,3-Benzoxazoles via oxidative cyclization of corresponding o-hydroxyarylidene anilines was synthesized in the presence of KMnO4/HOAc system. This system also was applied for the one-pot synthesis of 1,3-benzoxazoles from o-amino phenols and aldehydes. The both protocols were processed at room temperature under solvent-free conditions with good to excellent yields.
Microwave-assisted one-pot synthesis of benzothiazole and benzoxazole libraries as analgesic agents
Praveen,Nandakumar,Dheenkumar,Muralidharan,Perumal
experimental part, p. 609 - 624 (2012/08/28)
Microwave-assisted synthesis of benzothiazole and benzoxazole libraries via PIFA promoted cyclocondensation of 2-aminothiophenols/2-aminophenols with aldehydes under one-pot condition in good to excellent yields was achieved. Twenty compounds have been investigated for their analgesic activity and showed moderate to good activity. Indian Academy of Sciences.
Oxidative cyclization of thiophenolic and phenolic Schiff's bases promoted by PCC: a new oxidant for 2-substituted benzothiazoles and benzoxazoles
Praveen,Kumar, K. Hemanth,Muralidharan,Perumal
, p. 2369 - 2374 (2008/09/18)
Pyridinium chlorochromate (PCC) supported on silica gel effects the oxidative cyclization of structurally diverse thiophenolic and phenolic Schiff's bases, thereby providing an efficient and convenient method for the synthesis of a library of 2-arylbenzot
BENZOXAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION
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Page/Page column 40, (2008/06/13)
There is provided the use of a compound of formula (I),wherein Y, W1 to W4, Z1 to Z4 and R have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicame
2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: A novel class of small molecule heparanase inhibitors
Courtney, Stephen M.,Hay, Philip A.,Buck, Richard T.,Colville, Claire S.,Porter, David W.,Scopes, David I. C.,Pollard, Faye C.,Page, Martin J.,Bennett, James M.,Hircock, Margaret L.,McKenzie, Edward A.,Stubberfield, Colin R.,Turner, Paul R.
, p. 3269 - 3273 (2007/10/03)
A novel class of 2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acids are described as inhibitors of the endo-β-glucuronidase heparanase. Several of the compounds, for example, 2-[4-propylamino-5-[5-(4-chloro)phenyl-benzoxazol-2- yl]phenyl]-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid (9c), display potent heparanase inhibitory activity (IC50 200-500nM) and have high selectivity (>100-fold) over human β-glucuronidase. They also show anti-angiogenic effects. Such compounds should serve as useful biological tools and may provide a basis for the design of novel therapeutic agents.
