25287-47-2

Basic information

• Product Name: Benzenamine, 4-chloro-N-[1-(4-chlorophenyl)ethylidene]-
• CAS NO: 25287-47-2
• Molecular Formula: C14H11Cl2N
• Molecular Weight: 264.154
• Mol File: 25287-47-2.mol

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-chloro-N-[1-(4-chlorophenyl)ethylidene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-chloro-N-[1-(4-chlorophenyl)ethylidene]-(25287-47-2)
• EPA Substance Registry System: Benzenamine, 4-chloro-N-[1-(4-chlorophenyl)ethylidene]-(25287-47-2)

Safety Data

• Hazardous Substances Data: 25287-47-2(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 89500-36-7 4-chloro-N-(1-(4-chlorophenyl)ethyl)aniline 

Relevant articles and documents

Mn-catalyzed three-component reactions of imines/nitriles, grignard reagents, and tetrahydrofuran: An expedient access to 1,5-amino/keto alcohols

An expedient Mn-catalyzed three-component synthesis of 1,5-amino/keto alcohols from Grignard reagents, imines/nitriles, and tetrahydrofuran (THF) is described, which deviates from the classic Grignard addition to imines/nitriles in THF solvent. THF is split and sewn in an unprecedented manner in the reaction, leading to the formation of two geminal C-C bonds via C-H and C-O cleavage. Mechanistic experiments and DFT calculations reveal radical and organo-Mn intermediates in the catalytic cycle and the α-arylative ring-opening of THF as the key reaction step.