252947-88-9Relevant academic research and scientific papers
Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens
Kanbe, Yoshitake,Kim, Myung-Hwa,Nishimoto, Masahiro,Ohtake, Yoshihito,Tsunenari, Toshiaki,Taniguchi, Kenji,Ohizumi, Iwao,Kaiho, Shin-ichi,Nabuchi, Yoshiaki,Kawata, Setsu,Morikawa, Kazumi,Jo, Jae-Chon,Kwon, Hee-An,Lim, Hyun-Suk,Kim, Hak-Yeop
, p. 4090 - 4094 (2006)
In order to search for alternatives to the sulfoxide moiety in the long side chain of pure antiestrogens, several molecules that may interact with water in a fashion similar to ICI164,384 were designed and it was found that compounds with the carboxy, the
Benzopyran or thiobenzopyran derivatives
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Page/Page column 190, (2010/01/31)
The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: The present invention further provides pharmaceutical compositions which possess anti-estrogenic activity and comprise at least one benzopyran compound of the invention and a method of treating breast cancer by administration of an effective amount of a benzopyran compound provided by the present invention.
