252952-55-9Relevant academic research and scientific papers
A route to enantiomerically-enriched α-silyl aldehydes from 2,3-epoxy alcohols
Chauret, Denise C.,Chong, J. Michael,Ye, Qing
, p. 3601 - 3614 (2007/10/03)
Asymmetric epoxidation of (E)-3-trialkylsilyl-2-propen-1-ols gives the expected epoxides with high enantioselectivity. Ring opening reactions of these epoxides with organocopper reagents furnishes 1,2-diols which are readily cleaved with Pb(OAc)4 to afford α-silyl aldehydes with no detectable loss of stereochemistry.
