252990-19-5

Basic information

• Product Name: Desbutyl LuMefantrine
• Synonyms: Desbutyl LuMefantrine (E/Z-Mixture);Desbutyl LuMefantrine (E/Z-Mixture) See D289345 for pure (Z);Desbutyl LuMefantrine (E/Z-Mixture) Discontinued See D289345 for pure (Z)
• CAS NO: 252990-19-5
• Molecular Formula: C26H24Cl3NO
• Molecular Weight: 472.83386
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 252990-19-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 68-72°C
• Boiling Point: 626.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.321±0.06 g/cm3(Predicted)
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• PKA: 13.48±0.20(Predicted)
• CAS DataBase Reference: Desbutyl LuMefantrine(CAS DataBase Reference)
• NIST Chemistry Reference: Desbutyl LuMefantrine(252990-19-5)
• EPA Substance Registry System: Desbutyl LuMefantrine(252990-19-5)

Safety Data

• Hazardous Substances Data: 252990-19-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Foam

Uses

A metabolite of Lumefantrine (L474000).

Upstream product

• 7012-16-0 2,7-dichloro-9H-fluorene 
• 252990-25-3 2-n-Butylamino-1-(2,7-dichloro-9H-fluoren-4yl)ethanol 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Synthetic method of benzofluorenol-D9

The invention provides a synthesis method of benzofluorenol-D9, which comprises the following steps: 1) in the presence of anhydrous aluminum chloride, carrying out Friedel-Crafts reaction on a compound 1 and chloroacetyl chloride to obtain a compound 2; 2) performing reduction reaction on the compound 2 and sodium borohydride to obtain a compound 3; 3) performing substitution reaction on the compound 3 and n-butylamine to obtain a compound 4; 4) in the presence of alkali, carrying out condensation reaction on the compound 4 and p-chlorobenzaldehyde to prepare a compound 5; and 5) in the presence of potassium carbonate, subjecting the compound 5 and deuterated n-bromobutane-D9 to a substitution reaction so as to prepare benzofluorenol-D9. According to the method, the commercially availabledeuterated n-bromobutane-D9 is used as the deuterated raw material for the first time, the deuterated benzofluorenol-D9 is finally synthesized through a series of reactions, use of di-n-butylamine-D9is avoided, the deuterated raw material with high price is used as the last step of reaction raw material in the route, and cost reduction is facilitated.