2531-04-6

Basic information

• Product Name: piperylone
• Synonyms: piperylone;Piperylonum;4-Ethyl-1,2-dihydro-2-(1-methylpiperidin-4-yl)-5-phenyl-3H-pyrazol-3-one;4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one;4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one;PR66
• CAS NO: 2531-04-6
• Molecular Formula: C₁₇H₂₃N₃O
• Molecular Weight: 285.38
• EINECS: 219-788-4
• Mol File: 2531-04-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 413°Cat760mmHg
• Flash Point: 203.6°C
• Appearance: /
• Density: 1.121g/cm³
• Vapor Pressure: 4.96E-07mmHg at 25°C
• Refractive Index: 1.571
• PKA: pK1 5.90; pK2 9.15(at 25℃)
• CAS DataBase Reference: piperylone(CAS DataBase Reference)
• NIST Chemistry Reference: piperylone(2531-04-6)
• EPA Substance Registry System: piperylone(2531-04-6)

Safety Data

• Hazardous Substances Data: 2531-04-6(Hazardous Substances Data)

Usage

Originator

Palerol, Novartis

Manufacturing Process

A mixture of 8.8 parts of α-ethylbenzoylacetic acid ethyl ester and 5,3 parts of N-methyl-piperidyl-4-hydrazine is allowed to stand for 30 min at 22°C, after which the mixture is heated for 5 hours to 130°C under a pressure of 12 mm. After 4 hours 1-(N-methylpiperidyl-4)-3-phenyl-4-ethylpyrazolone-5 begins crystallize out. The reaction mixture is allowed to cool, after which the crystal mass is triturated with ether and then recrystallized from methanol-ether or from acetone. Melting point 159-161°C.

Therapeutic Function

Analgesic

InChI:InChI=1/C17H23N3O/c1-3-15-16(13-7-5-4-6-8-13)18-20(17(15)21)14-9-11-19(2)12-10-14/h4-8,14,18H,3,9-12H2,1-2H3