253128-35-7Relevant academic research and scientific papers
Macrocyclic ketone analogues of halichondrin B
Zheng, Wanjun,Seletsky, Boris M.,Palme, Monica H.,Lydon, Paul J.,Singer, Lori A.,Chase, Charles E.,Lemelin, Charles A.,Shen, Yongchun,Davis, Heather,Tremblay, Lynda,Towle, Murray J.,Salvato, Kathleen A.,Wels, Bruce F.,Aalfs, Kimberley K.,Kishi, Yoshito,Littlefield, Bruce A.,Yu, Melvin J.
, p. 5551 - 5554 (2007/10/03)
Synthesis and SAR studies of structurally simplified analogues of marine natural product halichondrin B resulted in the discovery of E7389, a new potential antitumor agent currently undergoing Phase I clinical trials. Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.
Intermediate compounds for preparing macrocylcic analogs
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Page column 64-66, (2008/06/13)
Intermediate compounds of the formulas for use in the preparation of macrocyclic analogs.
