25315-41-7Relevant academic research and scientific papers
Silver-catalyzed oxidative decarboxylation of difluoroacetates: Efficient access to C-CF2 bond formation
Wan, Wen,Ma, Guobin,Li, Jialiang,Chen, Yunrong,Hu, Qingyang,Li, Minjie,Jiang, Haizhen,Deng, Hongmei,Hao, Jian
, p. 1598 - 1601 (2016)
A mild, versatile and efficient method for the silver(i)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade reaction comprises the addition of an oxidatively generated difluoromethylene radical to the isonitrile functionality and subsequent homolytic aromatic substitution. It provides a novel and efficient access to the C-CF2 bond formation.
4CzIPN-tBu-Catalyzed Proton-Coupled Electron Transfer for Photosynthesis of Phosphorylated N-Heteroaromatics
Liu, Yan,Chen, Xiao-Lan,Li, Xiao-Yun,Zhu, Shan-Shan,Li, Shi-Jun,Song, Yan,Qu, Ling-Bo,Yu, Bing
supporting information, p. 964 - 972 (2021/01/12)
2,4,5,6-Tetrakis(3,6-di-tert-butyl-9H-carbazol-9-yl)isophthalonitrile (4CzIPN-tBu) was developed as a photocatalyst for the phosphorus-radical-initiated cascade cyclization reaction of isocyanides. By using 4CzIPN-tBu as catalyst, we developed a visible-light-induced proton-coupled electron transfer strategy for the generation of phosphorus-centered radicals, via which a wide range of phosphorylated phenanthridines, quinolines, and benzothiazoles were successfully constructed.
Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines
Xue, Dengqi,Xue, Yijie,Yu, Haihua,Shao, Liming
supporting information, p. 874 - 884 (2019/02/10)
A metal-free radical cyclization reaction of vinyl isocyanides with alkanes is developed, allowing convenient access to a diverse range of potentially valuable 1-alkylisoquinolines. The methodology is simple and efficient, demonstrating excellent functional group tolerance and broad substrate scope. A mechanism involving a radical process is supported by kinetic isotope effect and radical inhibition studies.
Mn(ii)/O2-promoted oxidative annulation of vinyl isocyanides with boronic acids: Synthesis of multi-substituted isoquinolines
Wang, Hao,Yu, Yang,Hong, Xiaohu,Xu, Bin
supporting information, p. 13485 - 13488 (2015/01/16)
An efficient manganese(ii)/O2-promoted oxidative radical cascade reaction was developed for the modular synthesis of multi-substituted isoquinolines from easily accessible vinyl isocyanides and boronic acids.
1-Trifluoromethylated isoquinolines via radical trifluoromethylation of isonitriles
Zhang, Bo,Studer, Armido
supporting information, p. 9895 - 9898 (2015/01/08)
A simple and efficient approach to biologically important 1-trifluoromethylated isoquinolines starting with readily prepared β-aryl-α-isocyano-acrylates and the commercially available Togni reagent as the CF3 radical precursor is described. The
