253168-87-5Relevant academic research and scientific papers
Copper-Catalyzed Synthesis of β-Azido Sulfonates or Fluorinated Alkanes: Divergent Reactivity of Sodium Sulfinates
Xiong, Yang,Sun, Youwen,Zhang, Guozhu
supporting information, p. 6250 - 6254 (2018/10/05)
A new and general method for the synthesis of β-azidosulfonates has been achieved through Cu(I)-mediated radical oxidative sulfonylation-azidation of alkenes with sodium sulfinates. Under identical conditions, azido fluoroalkyated products could be readily obtained instead using CF3SO2Na or CHF2SO2Na as reagents. The starting materials of sulfinate compounds, alkenes, and azidotrimethylsilane are stable and cheap. This method can be easily adapted for large-scale preparation.
Substituted phenethylsulfones and method of reducing TNF alpha levels
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, (2008/06/13)
Phenethylsulfones substituted in the position alpha to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNF alpha in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline-1,3-dione and 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindoline-1,3-dione.
