2532-15-2

Usage

Uses

Used in Organic Synthesis:
Sodium 4-bromobenzoate is used as a reagent for the preparation of aromatic carboxylic acids and their derivatives. Its unique structure allows for various chemical reactions, facilitating the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, sodium 4-bromobenzoate serves as a key intermediate in the synthesis of active pharmaceutical ingredients. Its properties enable the development of new drugs and contribute to the advancement of medicinal chemistry.
Used as a Precursor:
Sodium 4-bromobenzoate is often utilized as a precursor for the preparation of other organic compounds. Its reactivity and solubility make it an ideal starting material for the synthesis of various chemical entities, expanding its applications across different industries.

InChI:InChI=1/C7H5BrO2.Na/c8-6-3-1-5(2-4-6)7(9)10;/h1-4H,(H,9,10);/q;+1/p-1

Upstream product

• 18292-63-2 1-(p-bromobenzoyl)aziridine 
• 1122-91-4 4-bromo-benzaldehyde 
• 586-76-5 4-Bromobenzoic acid 
• 824-78-2 4-nitrophenol sodium salt 

Downstream Products

• 586-76-5 4-Bromobenzoic acid 
• 824-78-2 4-nitrophenol sodium salt 
• 1432747-08-4 2-[(2-furylmethyl)amino]-2-[5-(2-phenyl-1-ethynyl)-1,3,4-oxadiazol-2-yl]propyl 4-bromobenzoate 
• 1432747-06-2 2-[(4-methylbenzyl)amino]-2-[5-(2-phenyl-1-ethynyl)-1,3,4-oxadiazol-2-yl]propyl 4-bromobenzoate 
• 1432747-12-0 2-[(4-methoxybenzyl)amino]-2-[5-(2-phenyl-1-ethynyl)-1,3,4-oxadiazol-2-yl]propyl 4-bromobenzoate 
• 900937-58-8 2-oxopropyl 4-bromobenzoate 
• 1431463-30-7 2-hydroxy-2-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]propyl 4-bromobenzoate 
• 1431463-29-4 2-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl 4-bromobenzoate 
• 1431463-28-3 2-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl 4-bromobenzoate 
• 1186200-21-4 3-methyl-2-(pyridin-2-yl)phenyl 4-bromobenzoate 
• 619-64-7 p-ethylbenzoic acid 
• 864720-93-4 [(4-bromobenzoato)bis(N-(5-methylthiazol-2-yl)thiazole-2-carboxamidate)tetrakis(4-bromobenzoato)(μ3-oxo)triiron(III)] 
• 100477-66-5 silver(I) p-bromobenzoate 

Relevant academic research and scientific papers

The effect of 4-halogenobenzoate ligands on luminescent and structural properties of lanthanide complexes: Experimental and theoretical approaches

The ligands 4-fluorobenzoate (4-fba), 4-chlorobenzoate (4-cba), 4-bromobenzoate (4-bba) and 4-iodobenzoate (4-iba) were chosen in order to synthesize europium(iii), gadolinium(iii) and terbium(iii) complexes and compare the effect of halogens on their phy

Electronic and steric effects: How do they work in ionic liquids? the case of benzoic acid dissociation

(Figure Presented) The need to have a measure of the strength of some substituted benzoic acids in ionic liquid solution led us to use the protonation equilibrium of sodium p-nitrophenolate as a probe reaction, which was studied by means of spectrophotometric titration at 298 K. In order to evaluate the importance of electronic effect of the substituents present on the aromatic ring, both electron-withdrawing and -donor substituents were taken into account. Furthermore, to have a measure of the importance of the steric effect of the substituents both para- and ortho-substituted benzoic acids were analyzed. The probe reaction was studied in two ionic liquids differing for the ability of the cation to give hydrogen bond and π-π interactions, namely [bm 2im][NTf2] and [bmpyrr][NTf2]. Data collected show that benzoic acids are less dissociated in ionic liquid than in water solution. Furthermore, the equilibrium constant values seem to be significantly affected by both the nature of ionic liquid cation and the structure of the acid. In particular, the ortho-steric effect seems to operate differently in water and in the aromatic ionic liquid, determining in this solvent medium a particular behavior for ortho-substituted benzoic acids.

Effect of Distortion on the Hydrolytic Reactivity of Amides. 2. N-Pyramidalization: Decomposition of N-Benzoylaziridines in Aqueous Media

The decomposition of para-substituted N-benzoylaziridines (H, OCH3, NO2, Br) in buffered aqueous media is studied at 25 deg C as a function of pH in order to assess the effect of N-pyramidalization on the hydrolytic reactivity of the amide bond.Overall, the reaction shows three dominant terms: OH- and H2O attack on the neutral form and H2O attack on the protonated form of the amide.In base, the exclusive reaction is rate-limiting and irreversible attack of OH- on the C=O unit leading to normal hydrolytic products.This is shown by the first-order dependence on -> from pH 8 to 14 of the hydrolysis rate and by the fact that ca. 50percent 18O-enriched amide recovered from the hydrolysis medium as a function of time shows no 18O loss.Relative to N,N-dimethylbenzamide (kOH-25 deg C = 6.0 * 10-6 M-1 s-1), N-benzoylaziridine is ca. 200 000-fold more susceptible to OH- attack (kOH-25 deg C = 1.1 M-1 s-1).The kOH- terms follow a ?ρ relationship with ρ = 1.68.In acid, the products are not the expected hydrolytic ones of benzoic acid and aziridine.Rather, exclusive ring opening occurs to give p-X-C6H4C(=O)NHCH2CH2OX.In acetate buffers, product analysis by 1H NMR indicates that the ring-opened material consists of alcohol and acetate (X = H and C(=O)CH3).

Kinetics and Mechanism of Ru(III)-catalysed Oxidation of Aromatic Aldehydes by Sodium Metaperiodate in Alkaline Medium: A Change in Mechanism from Hydride Loss in Acid Medium to Proton Loss in Alkaline Medium

The title reactions are first order in the substrate and first order in the catalyst, the order with respect to periodate being zero.The dependence on alkali is unity.The reactivity order is p-nitro > m-nitro > m-bromo > m-methoxy > p-bromo > p-chloro- > H ca. p-methyl > p-methoxy.The pH-rate profile attains a minimim at neutral pH and the rate increases on either regions of this pH.The Hammett plot shows a fair linearity with a ρ-value of + 1.66 pointing to a rate-limiting proton loss.A mechanism involving the complexation of the monoanion of the aldehydes with the Ru(III) followed by rate-limiting proton loss is postulated.Activation parameters have been computed.