2532-71-0Relevant academic research and scientific papers
α-Hydroxy-Tetrazoles as Latent Ethynyl Moieties: A Mechanistic Investigation
Quinodoz, Pierre,Wright, Karen,Drouillat, Bruno,Kletskii, Mikhail E.,Burov, Oleg N.,Lisovin, Anton. V.,Couty, Fran?ois
, (2018/05/03)
This article focuses on the dehydration of α-hydroxy-tetrazoles, leading to tetraazafulvenes and then to vinylic carbenes that rearrange into ethynyl moieties through the Fritsch-Buttenberg-Wiechell rearrangement. Each step of this sequence was scrutinized, either by examination of the substrate and/or dehydrating agent scope, or through AM1 calculations, in order to understand the limiting step of this process. This underrated transformation appears to be a viable alternative to existing methods used for transforming aldehydes into alkynes.
SYNTHESIS OF 5-ALKYNYLIDENE-OXAZOLIDIN-2-ONES
Tam, Tim F.,Thomas, Everton,Krantz, Allen
, p. 1127 - 1130 (2007/10/02)
N-Carboethoxy-N-alkyl-propargylamines react with iodine, silver tetrafluoroborate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to give N-alkyl-5(E)-iodomethylidene-oxazolidin-2-ones which can be converted to the corresponding 5-alkynyli
