25327-57-5

Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-4-carboxylic acid, anhydride is used as a key intermediate for the synthesis of various pharmaceuticals. Its ability to participate in organic reactions makes it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, [1,1'-Biphenyl]-4-carboxylic acid, anhydride is utilized as a starting material for the production of various agrochemicals. Its involvement in organic synthesis contributes to the development of effective pesticides, herbicides, and other agricultural chemicals.
Used in Materials Science:
[1,1'-Biphenyl]-4-carboxylic acid, anhydride also finds application in the field of materials science. It is used as a component in the development of new materials with specific properties, such as polymers, composites, and other advanced materials.

Upstream product

• 3218-36-8 4-Phenylbenzaldehyde 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 3597-91-9 biphenyl-4-yl methanol 
• 92-92-2 biphenyl-4-carboxylic acid 
• 201230-82-2 carbon monoxide 
• 1591-31-7 4-iodo-biphenyl 

Downstream Products

• 71203-40-2 norethisterone 4-phenylbenzoate 
• 1246196-60-0 C₄₅H₅₆O₁₂ 
• 2714-87-6 [1,1′-biphenyl]-4-carbonyl fluoride 
• 131227-77-5 Methyl 2-deoxy-2-(N,N-dimethylamino)-3-O-methyl-α-D-mannopyranoside 4,6-diphenylbenzoate 
• 131227-78-6 Methyl 2-deoxy-2-(N,N-dimethylamino)-α-D-mannopyranoside 3,4,6-triphenylbenzoate 

Relevant academic research and scientific papers

Metal-free oxidative self-coupling of aldehydes or alcohols to symmetric carboxylic anhydrides

A metal-free synthesis of symmetrical anhydrides has been developed starting from aldehydes, both aliphatic and aromatic or primary benzylic alcohols. The reaction occurs at room temperature and makes use of trichloroisocyanuric acid (TCCA) as an oxidant providing the desired carboxylic anhydrides in satisfactory yields.

Anhydrides from aldehydes or alcohols via oxidative cross-coupling

A novel type of metal-free oxidative cross-coupling for the synthesis of symmetrical and mixed anhydrides from aldehydes or benzylic alcohols has been developed. The aldehydes or alcohols were converted in situ into their corresponding acyl chlorides, which were then reacted with an array of carboxylic acids. The methodology has a general applicability, and was successfully employed to prepare either aromatic or aliphatic symmetrical anhydrides and mixed anhydrides, which are very unstable compounds.

Carboxylic acid anhydrides via Pd-catalyzed carbonylation of aryl halides at atmospheric CO pressure

A convenient method has been developed, which allows for the direct transformation of aryl iodides into the corresponding carboxylic acid anhydrides via Pd-catalyzed carbonylation under atmospheric CO pressure. The Royal Society of Chemistry 2012.

ZnCl2-mediated synthesis of carboxylic anhydrides using 2-acyl-4,5-dichloropyridazin-3(2H)-ones

ZnCl2 is an efficient catalyst for synthesis of carboxylic acid anhydride from 2-acyl-4,5-dichloropyridazin-3(2H)-ones. Treatment of 2-acyl-4,5-dichloropyridazin-3(2H)-ones with ZnCl2 (0.5 equivalents) and air in refluxing dry THF or