253307-68-5

Upstream product

• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 253307-69-6 C₂₅H₃₂N₄O₇ 
• 631897-22-8 4-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 340961-33-3 (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 340961-34-4 1-(N-[tert-butoxycarbonylaminoethyl])-(4S)-(N⁴-benzyloxycarbonylcytosin-1-yl)-2-(S)-proline methyl ester 

Relevant academic research and scientific papers

Hybrid DNA i-motif: Aminoethylprolyl-PNA (pC5) enhance the stability of DNA (dC5) i-motif structure

This report describes the synthesis of C-rich sequence, cytosine pentamer, of aep-PNA and its biophysical studies for the formation of hybrid DNA:aep-PNAi-motif structure with DNA cytosine pentamer (dC5) under acidic pH conditions. Herein, the CD/UV/NMR/ESI-Mass studies strongly support the formation of stable hybrid DNA i-motif structure with aep-PNA even near acidic conditions. Hence aep-PNA C-rich sequence cytosine could be considered as potential DNA i-motif stabilizing agents in vivo conditions.

Aminoethylprolyl peptide nucleic acids (aepPNA): chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes.

[formula: see text] The replacement of the glycyl component in the peptide nucleic acid (PNA) backbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity, forming highly stable triplexes.