253311-87-4Relevant academic research and scientific papers
Determination of absolute configurations of tertiary alcohols by NMR spectroscopy
Takahashi, Haruko,Kato, Naoko,Iwashima, Makoto,Iguchi, Kazuo
, p. 1181 - 1182 (2007/10/03)
A method has been developed for determining the absolute configurations of acyclic tertiary alcohols using their 2NMA [methoxy-(2-naphthyl)acetic acid] esters. The 1H NMR spectra of (R)-and (S)-2NMA esters of model compounds were measured, and Δδ values (δR-ester - δS-ester) were calculated. The absolute configuration for tertiary hydroxy group is determined based on the sign of Δδ values like that for secondary hydroxy group.
