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Usage

Uses

Used in Pharmaceutical Industry:
7-Iodoquinoline is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of anticancer agents, antimalarial drugs, and other therapeutic compounds. Its chemical structure facilitates the creation of complex organic molecules that can target specific biological pathways or diseases.
Used in Chemical Research:
As a reagent, 7-Iodoquinoline is utilized in chemical research to explore new synthetic pathways and develop innovative organic compounds. Its properties make it a valuable tool for understanding and manipulating chemical reactions in the lab.
Used in Agrochemical Production:
7-Iodoquinoline is employed in the production of agrochemicals, where it serves as a component in the synthesis of compounds designed to protect crops and enhance agricultural productivity. Its role in this industry underscores its broad applicability across different sectors.
Used in the Synthesis of Fluorescent Dyes:
7-Iodoquinoline is used as a precursor in the synthesis of fluorescent dyes, which have applications in various fields such as bioimaging, diagnostics, and as markers in research. 7-Iodoquinoline's ability to absorb and emit light makes it a suitable candidate for these applications.

Upstream product

• 851985-81-4 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline 
• 580-19-8 quinolin-7-ylamine 

Downstream Products

• 942947-13-9 1-(Quinolin-7-yl)-4-(4-(trifluoromethyl)phenyl)piperidin-2-one 
• 629644-82-2 quinolin-7-yl-boronic acid 

Relevant academic research and scientific papers

Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary

Pd-catalyzed β-C-H functionalizations of carboxylic acid derivatives using an auxiliary as a directing group have been extensively explored in the past decade. In comparison to the most widely used auxiliaries in asymmetric synthesis, the simplicity and practicality of the auxiliaries developed for C-H activation remains to be improved. We previously developed a simple N-methoxyamide auxiliary to direct β-C-H activation, albeit this system was not compatible with carboxylic acids containing α-hydrogen atoms. Herein we report the development of a pyridine-type ligand that overcomes this limitation of the N-methoxyamide auxiliary, leading to a significant improvement of β-arylation of carboxylic acid derivatives, especially α-amino acids. The arylation using this practical auxiliary is applied to the gram-scale syntheses of unnatural amino acids, bioactive molecules, and chiral bis(oxazoline) ligands.

LIGAND-CONTROLLED C(SP3)-H ARYLATION AND OLEFINATION IN SYNTHESIS OF UNNATURAL CHIRAL ALPHA AMINO ACIDS

The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

Vanilloid receptor ligands and their use in treatments

Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache,

Vanilloid receptor ligands and their use in treatments

Substituted nitrogen-containing heterocycles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension hea