253344-32-0

Upstream product

• 515-94-6 (S)-2,3-diaminopropionic acid 
• 3674-06-4 Boc-Phe-ONSu 

Downstream Products

• 253344-34-2 {1-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-1-hydroxymethyl-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 1026541-61-6 (S)-2-Amino-N-[(S)-2-((S)-2-amino-3-phenyl-propionylamino)-1-hydroxymethyl-ethyl]-3-phenyl-propionamide 

Relevant academic research and scientific papers

Symmetry-based inhibitors of HIV-1 protease. Design, synthesis and preliminary structure-activity studies of acylated 2,3-diamino-1- hydroxypropanes and 2,4 diamino-1-hydroxybutanes

Two series of peptidomimetics containing a novel C2 pseudosymmetrical hydroxyalkyldiamino core structure were prepared from amino acid starting materials and tested for inhibitory activity against the HIV-1 protease (HIV- 1 Pt) and the virus in cell culture. In the 2,3-diamino-1-hydroxypropane series, compound 6a, containing P1/P1(I) benzyl and P2/P2(I) Fmoc substituents, displayed modest HIV-1 Pr inhibition (IC50 = 430 nM). The corresponding 2,4-diamino-1-hydroxybutane derivative (6b) was the best inhibitor of the series (IC50 = 160 nM). Interestingly, 6a and 6b showed satisfactory inhibition of HIV replication in cell culture. (ED50 = 340 and 110 nM, respectively), a result which suggests good cell membrane penetration by this class of compounds.