253350-40-2

Upstream product

• 1515-89-5 3-(methoxymethyl)bromobenzene 
• 253350-38-8 (3S)-4-(3-methoxymethylphenyl)-1-butyn-3-ol 
• 253350-32-2 (2S)-3-(3-methoxymethylphenyl)-1-acetyloxypropan-2-ol 
• 253350-31-1 (2S)-3-(3-methoxymethylphenyl)propan-1,2-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 253350-39-9 3-(S)-t-butyldimethylsilyloxy-4-(3-methoxymethylphenyl)-1-butyne 
• 253350-30-0 (2S)-3-(3-methoxymethylphenyl)-1-triphenylmethoxypropan-2-ol 
• 253350-33-3 1-acetoxy-3-(3-methoxymethylphenyl)-2-(S)-tetrahydropyranyloxypropane 
• 253350-36-6 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-methoxymethylphenyl)-1-butene 
• 253350-34-4 2-(S)-tetrahydropyranyloxy-3-(3-methoxymethylphenyl)propan-1-ol 
• 253350-35-5 2-(S)-tetrahydropyranyloxy-3-(3-methoxymethylphenyl)propan-1-al 

Downstream Products

• 256382-35-1 4-{2-[(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopent-(E)-ylidene]-ethylsulfanyl}-butyric acid methyl ester 
• 256382-36-2 methyl 4-({2-[(1R,2R,3S)-3-{[dimethyl(2-methyl-2-propanyl)silyl]-oxy}-2-{(1E,3S)-3-{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxocyclopentyl]ethyl}sulfanyl)-butanoate 
• 443147-09-9 (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester 
• 261772-69-4 7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester 
• 261772-70-7 7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-(toluene-4-sulfonyloxy)-cyclopentyl]-heptanoic acid methyl ester 
• 1369917-49-6 ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate 
• 1369917-48-5 C₂₉H₅₁NO₆SSi 
• 1369917-43-0 (2E,4S)-4-(tert-butyldimethylsilyloxy)-5-[3-(methoxymethyl)phenyl]-2-penten-1-ol 
• 1369916-94-8 (11R,12R,13E,15S)-11,15-dihydroxy-16-(3-methoxymethylphenyl)-17,18,19,20-tetranorprost-8,13-dienoic acid 
• 1369917-11-2 (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester 
• 1369917-08-7 (7E)-7,8-didehydro-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester 
• 1369916-93-7 (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 
• 1369917-19-0 C₂₅H₃₆O₅ 
• 1369917-02-1 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid 

Relevant academic research and scientific papers

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

To identify a new selective EP4-agonist with improved chemical stability, further chemical modification of those reported previously was continued. We focused our attention on chemical modification of the alpha chain of 3,7-dithiaPGE(1) and selected 5-thi

5-thia-ω-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient

The present invention relates to 5-thia-ω-substituted phenylprostaglandin E derivatives of the formula (I) (wherein, all the symbols are as defined in the specification), process for producing them and pharmaceutical compositions comprising them as active

γ(v)-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

An ω-substituted phenyl-prostaglandin derivative of formula (I), a process for the preparation thereof, a medicament comprising it as active ingredient (all symbols have the same meaning as described in the specification). The compounds of the formula (I)

3,7-dithiaprostanoic acid derivative

A 3,7-dithiaprostanoic acid derivative of the formula (I) STR1 (wherein, R1 is OH, C16 alkyloxy, NR6 R7 (R6, R7 are H, C16 alkyl.); R2 is H, OH; R3 is single bond, C16 alkylene; R4 is (i) C18 alkyl substituted by C16 alkyloxy, halogen etc., (ii) phenyloxy