25356-95-0

Basic information

• Product Name: p-chloro-alpha-methyl-phenethylamin hydrochloride
• Synonyms: p-chloro-alpha-methyl-phenethylamin hydrochloride;1-(4-chlorophenyl)propan-2-amine hydrochloride;Benzeneethanamine, 4-chloro-alpha-methyl-, hydrochloride (9ci);p-Chloramphetamine hydrochloride;Phenethylamine, p-chloro-alpha-methyl-, hydrochloride;Ro 4-6614/001
• CAS NO: 25356-95-0
• Molecular Formula: C9H13Cl2N
• Molecular Weight: 0
• Mol File: 25356-95-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: p-chloro-alpha-methyl-phenethylamin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: p-chloro-alpha-methyl-phenethylamin hydrochloride(25356-95-0)
• EPA Substance Registry System: p-chloro-alpha-methyl-phenethylamin hydrochloride(25356-95-0)

Safety Data

• Hazardous Substances Data: 25356-95-0(Hazardous Substances Data)

Upstream product

• 3706-38-5 p-chloroamphetamine hydrochloride 

Relevant articles and documents

Preparation method of chiral alpha-methyl arylethylamine

The invention provides a preparation method of chiral alpha-methyl arylethylamine, and relates to the technical field of organic synthesis medicines. Boc-amino acid methyl ester is used as an initial raw material, Boc-amino alcohol is obtained through reduction, Boc-amino alcohol reacts with thionyl chloride and is oxidized through sodium periodate to obtain a sulfonamide compound, and then the sulfonamide compound is reduced through sodium borohydride promoted by lewis acid and a protecting group is removed under the acidic condition to obtain a target compound. According to the method, raw materials are cheap and easy to obtain, a single optical isomer product is obtained by using chiral raw materials, the problem of column chromatography resolution is solved, generation of a large amount of solid wastes and isomers is avoided, atom economy is improved, the product purity is high, the yield is high, and the production cost is effectively reduced. In addition, the mild reduction system is used for replacing the original high-pressure hydrogenation reaction, the process operation is relatively simple, and the method is more suitable for large-scale industrial production.

Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents

A method for the treatment of emesis in a mammal, which method comprises administering to said mammal an emesis inhibiting amount of a compound which depletes serotonin in the brain of mammals; among which are compounds having the formula: STR1 wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R1 and R2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof; two of the preferred compounds of the invention are fenfluramine and norfenfluramine.