253589-60-5Relevant academic research and scientific papers
The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds
Perrey, David A.,Scannell, Michael P.,Narla, Rama Krishna,Uckun, Fatih M.
, p. 551 - 552 (2007/10/03)
A series of cysteine chloromethyl ketone compounds with a systematic variation of the S-alkyl chain length have been synthesized in order to gauge the effect of the alkyl chain length on the cytotoxicity of these compounds against human acute lymphoblastic leukemia cells. Comparable activities were observed for compounds with S-alkyl chains ranging from pentyl to dodecyl, with the best being undecyl (IC50 = 1.7 μM) and dodecyl (IC50 = 2.0 μM) against B-lineage leukemia cells and hexyl (IC50 = 0.7 μM) against T-lineage leukemia cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity
Perrey, David A.,Narla, Rama Krishna,Uckun, Fatih M.
, p. 547 - 549 (2007/10/03)
A series of cysteine diazomethyl- and chloromethyl ketone derivatives has been synthesized and evaluated against human B-lineage (Nalm-6) and T-lineage (Molt-3) acute lymphoblastic leukemia cell lines. The chloromethyl ketone compounds showed potent cytotoxicity against these cell lines, with IC50 values in the low micromolar range. The best compounds were N-acetyl-S-dodecyl-Cys chloromethyl ketone (IC50 = 2.0 μM against Nalm-6, 2.3 μM against Molt-3) and N-acetyl-S-trans,trans-farnesyl-Cys chloromethyl ketone (IC50 = 3.0 μM against Nalm-6 and 1.4 μM against Molt-3). (C) Elsevier Science Ltd. All rights reserved.
