2536-99-4

Usage

Uses

Used in Molecular Biology Research:
Cytidylyl-(3'->5')-cytidine is utilized as a research tool for studying the mechanisms of RNA synthesis, stability, and degradation. It aids in understanding the role of CTP in RNA production and the impact of RNA modifications on the function and stability of RNA molecules.
Used in Drug Development:
Cytidylyl-(3'->5')-cytidine is employed as a potential therapeutic agent in the development of drugs targeting RNA metabolism-related diseases. Its involvement in RNA synthesis and modification makes it a promising candidate for the treatment of conditions associated with abnormal RNA function.
Used in Diagnostic Applications:
Cytidylyl-(3'->5')-cytidine can be used as a biomarker in diagnostic tests to assess RNA metabolism and the presence of specific RNA modifications, which may be indicative of certain diseases or conditions.
Used in Biochemical Education:
As a component of RNA synthesis and modification, cytidylyl-(3'->5')-cytidine is used as an educational tool in teaching the fundamentals of molecular biology, RNA metabolism, and the role of nucleotides in biological processes.

Upstream product

• 633-90-9 cytidine 2',3'-cyclic monophosphate 
• 65-46-3 CYTIDINE 
• 6554-17-2 N,O^3',O^5'-tribenzoylcytidine 
• 80186-08-9 C₇₀H₇₂ClN₆O₁₉P 
• 71933-67-0 dmtbzCtp(qcl)bzCt 
• 74231-44-0 C₅₁H₅₃ClN₇O₁₆P 
• 69673-09-2 cytidine-5'-phosphoro-(2-aminoimidazole) 
• 80186-00-1 triethylammonium salt of N⁴-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)-5'-O-(methoxytrityl)cytidine 3'-(2-chlorophenyl phosphate) 
• 77451-35-5 N⁴-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)cytidine 
• 80185-90-6 2',3'-O-(α-methoxybenzylidene)cytidine 
• 31505-92-7 N⁴-benzoyl-2'-O-tetrahydropyranylcytidine 
• 69359-38-2 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine 

Downstream Products

• 84-52-6 cytidine 3'-monophosphate 
• 85-94-9 cytidine-2'-monophosphate 
• 65-46-3 CYTIDINE 
• 633-90-9 cytidine 2',3'-cyclic monophosphate 

Relevant academic research and scientific papers

SITE-SPECIFIC MODIFICATION OF THE PYRIMIDINE RESIDUE DURING THE DEPROTECTION OF THE FULLY-PROTECTED DIURIDYLIC ACID.

A study of four different O-4 and N-3 protected uridine derivatives, 4 to 7, for their stabilities under different conditions versus their abilities to undergo nucleophilic substitution reaction at C-4 by an appropriate oxygen or a nitrogen nucleophile has established a general strategy for the site-specific modification of a particular pyrimidine residue in a model fully protected diuridylic acid to give either UpC, CpC or UpU, depending upon the deprotection condition.

Synthesis of 2'(3')-O-Aminoacyl Triribonucleoside Diphosphates Using the Triester Method

Specific syntheses of 2'(3')-O-aminoacyl triribonucleoside diphosphates, C-C-A-Phe (16e), C-C-A-Ala (16f), and C-C-A-Gly (16g), which are the terminal sequences of corresponding aa-tRNAs and potential substrates for ribosomal peptidyltransferase, are described.The compounds 16e-g were synthesized by employing phosphotriester methods with a benzoyl group for protection of heterocyclic amino groups, a 2-chlorophenyl group for internucleotide phosphate protection, a monomethoxytrityl group for blocking of the 5'-hydroxy function, a 4-methoxytetrahydropyranyl group forprotection of 2'-hydroxy functions, and an N-benzyloxycarbonyl group for blocking of the α-amino acid.Protected dinucleotide block C-Cp (11b) was synthesized via the triester method and was condensed by using mesitylenesulfonyl tetrazolide with nucleoside components 9b and 10b, which have aminoacyl residues incorporated in the molecule, to yield protected aminoacyl trinucleotides 13a and 14 in 60-70percent yields.The fully protected aminoacyl trinucleotides 13a and 13b were also obtained from the protected C-C-A derivative 12 (with a free 3'-OH group on the 3'-terminus) by the aminoacylation reaction with corresponding N-benzyloxycarbonyl amino acids and mesitylenesulfonyl tetrazolide in 50-70percent yields.The protected derivatives 13a,b and 14 were deblocked to form C-C-A(Z-Phe) (16b), C-C-A(Z-Ala) (16c), and C-C-A(Z-Gly) (16d) in 15-40percent yields by reactions with N2H4, F-, and H+ (for 16b,c) or NH4OH and H+ (for 16d).The final products 16e-g were prepared by hydrogenolysis (Pd/BaSO4) of 16b-d in practically quantitative yields.The syntheses of all components (3a,c,4,9a,b, and 10b) for the triester approach to aminoacyl trinucleotides are also described.