253603-03-1Relevant articles and documents
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Nacro, Kassoum,Bienfait, Bruno,Lee, Jeewoo,Han, Kee-Chung,Kang, Ji-Hye,Benzaria, Samira,Lewin, Nancy E.,Bhattacharyya, Dipak K.,Blumberg, Peter M.,Marquez, Victor E.
, p. 921 - 944 (2007/10/03)
The design of potent protein kinase C (PK-C) ligands with low nanomolar binding affinities was accomplished by the combined use of pharmacophore- and receptor-guided approaches based on the structure of the physiological enzyme activator, diacylglycerol (