253609-04-0Relevant articles and documents
A convenient preparation of difficultly accessible sec- alkylmethylphosphinates using sequential Pudovik/Abramov-Barton/McCombie reactions
Hansen, Henrik I.,Kehler, Jan
, p. 1925 - 1930 (1999)
A one-pot procedure for the syntheses of (1-hydroxy-sec- alkyl)methylphosphinates from ketones, hexamethyldisilazane and ethyl methylphosphinate was developed. The hydroxy group could be removed by a modified Barton/McCombie radical deoxygenation procedure. The sec- alkylmethylphosphinates can be dealkylated/hydrolyzed by treatment with trimethylsilyl bromide or refluxing in hydrochloric acid. This is a convenient route to a variety of sec-alkylmethylphosphinates, which are difficult to prepare by other methods.
