253609-29-9

Upstream product

• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 83976-41-4 (S)-2-methoxymethylpyrrolidine cyclohexanone enamine 
• 133696-29-4 (1R,5R)-2-(1-Cyclohexen-1-yl)-2-azabicyclo<3.3.0>octan 
• 133616-97-4 (1S,5S)-2-(1-Cyclohexen-1-yl)-2-azabicyclo<3.3.0>octan 
• 156473-27-7 (3aR,6aR)-octahydrocyclopentapyrrole 

Downstream Products

• 161972-08-3 (1R,2R)-2-phenylmethyl-cyclohexanol 
• 253609-32-4 (1R,1'S,1''R,2R,5''R)-2-[phenyl-1'-(2''-azabicyclo[3.3.0]octane-2''-ylmethyl)methyl]cyclohexanol 

Relevant academic research and scientific papers

Highly stereoselective synthesis of 1,3-aminoalcohols via Mannich reactions

Diastereoselective synthesis of β-amino ketones by a one-pot Mannich reaction and their subsequent reduction afforded sterically congested enantiomerically pure 1,3-aminoalcohols in high diastereoselectivity: dr up to >98:2 over two steps. The absolute configurations of the newly created stereogenic centers were assigned by NMR spectroscopy and chemical correlation.