25364-68-5

Upstream product

• 203861-67-0 (Z)-N-(4-methylbenzylidene)methylamine N-oxide 
• 614-16-4 Benzoylacetonitrile 
• 613-90-1 benzoyl cyanide 
• 766-97-2 4-n-methylphenylacetylene 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 104-87-0 4-methyl-benzaldehyde 
• 614-16-4 Benzoylacetonitrile 
• 75617-43-5 3,5-dicyano-4-(p-methylphenyl)-2,6-diphenyl-1,4-dihydropyridine 
• 76593-38-9 4-Cyano-3-hydroxy-3-phenyl-5-p-tolyl-tetrahydro-thiophene-2-carboxylic acid methyl ester 
• 95104-54-4 5-Benzoyl-2-thioxo-4,6-di-p-tolyl-hexahydro-pyrimidine-5-carbonitrile 
• 95104-58-8 5-Benzoyl-2-oxo-4,6-di-p-tolyl-hexahydro-pyrimidine-5-carbonitrile 
• 75238-81-2 3,5-dicyano-6-hydroxy-4-(p-methylphenyl)-6-phenyl-2-piperidone 
• 137934-91-9 E-2-benzoyl-2-cyano-3-(4-methylphenyl) cyclopropane-1,1-dicarboxylate de diethyle 
• 137934-90-8 4-cyano-3-(methylphenyl)-5-phenyl2,3-dihydrofurane-2,2-dicarboxylate de diethyle 
• 86625-30-1 1,2-Dihydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-3,5-pyridinedicarbonitrile 
• 86625-35-6 4,4'-Bis(4-methylphenyl)-6,6'-diphenyl-2,2'-dithiobis(3,5-pyridinedicarbonitrile) 
• 100784-40-5 3-carbamoyl-5-cyano-6-hydroxy-6-phenyl-4-(p-tolyl)-piperidin-2-one 
• 76593-44-7 4-Cyano-3-hydroxy-3-phenyl-5-p-tolyl-tetrahydro-thiophene-2-carboxylic acid ethyl ester 
• 102146-55-4 6-(4'-Acetyl-biphenyl-4-yl)-2-phenyl-4-p-tolyl-nicotinonitrile 

Relevant academic research and scientific papers

Magnesium Halide-Catalyzed Synthesis of Oxaspiro[2.5]octenes from a Methylenecyclopropane and Acyl Cyanoalkenes

MgX2-catalyzed annulation of methylenecyclopropanes with acyl cyanoalkenes was accomplished to give oxaspiro[2.5]octenes in excellent yields. The reaction proceeded through a rare intramolecular oxa-Michael addition of Mg enolate. The oxaspiro

Substituent-Controlled Divergent Cascade Cycloaddition Reactions of Chalcones and Arylalkynols: Access to Spiroketals and Oxa-Bridged Fused Heterocycles

Herein, we report substituent-controlled divergent cascade cycloaddition reactions of chalcones and arylalkynols in the presence of PtI2. Depending on the substituent on the chalcone, either spiroketals or oxa-bridged fused heterocycles could be obtained in the ranges of 86–97% and 87–95% yields under identical reaction conditions. Control experiments were carried out to elucidate the origin of the high chemoselectivity. These provide a method for the synthesis of a diverse array of structurally complex oxygen-containing heterocycles. (Figure presented.).

Dienamine-Mediated Asymmetric Inverse-Electron-Demand Hetero-Diels–Alder Reaction of Linear Deconjugated Enones: Diversity-Oriented Synthesis of 3,4-Dihydropyrans

The first organocatalytic asymmetric inverse-electron-demand Diels–Alder reaction of deconjugated enones by using a linear dienamine was explored. Electron-poor oxadienes having a cyano group were found to be suitable in this reaction. With a 20 mol-% loa

Organocatalytic Asymmetric [4+2] Cycloaddition of 1-Acetylcyclopentene and 1-Acetylcyclohexene for the Synthesis of Fused Carbocycles

The first organocatalytic asymmetric [4+2]-cycloaddition reaction of 1-acetylcyclopentenes and 1-acetylcyclohexenes was developed. Enones having cyano groups were used as the dienophiles in this method. The reaction provides a useful practical route to th

Stereospecific synthesis of polysubstituted E-olefins by reaction of acyclic nitrones with free and platinum(II) coordinated organonitriles

(Chemical Equation Presented) Free nitriles NCCH2R (1a R = CO2Me, 1b R = SO2Ph, and 1c R = COPh) with an acidic α-methylene react with acyclic nitrones -O+N(Me)= C(H)R′ (2a R′ = 4-MeC6Hsub

Palladium-Catalyzed Acylcyanation of Terminal Arylacetylenes. Synthesis of 1,3-Diaryl-3-cyano-2-propen-1-ones and Tetrasubstituted Furans

(Z)-1,3-Diaryl-3-cyano-2-propen-1-ones ((Z)-1) are prepared from arenecarbonyl cyanide and terminal arylacetylene in the presence of Pd(OAc)2-PPh3 (1 mol amt. to Pd)-0.5dppb (1,4-bis(diphenylphosphino)butane) (0.5 mol amt. to Pd). The reaction proceeded via the formation of acetylenic ketone 3, followed by the palladium-catalyzed addition of HCN, and isomerization of the resulting (E)-1 to (Z)-1. Oxidative addition of arenecarbonyl cyanide to zero-valent palladium metal has been observed by admixture of 4-MeOC6H4COCN to Pd2(dba)3 · CHCl3-PPh3-0.5dppb oxide (dppb oxide = Ph2P(O)(CH2)4P(O)Ph2). The resulting Pd(4-MeOC6H4CO)(CN)(PPh3)(ligand) afforded (Z)-1c by reaction with phenylacetylene. Thus, the role of two kinds of phosphine, PPh3 and dppb, suggests that the former acts as a ligand and the latter works as a reductant of Pd(II). The product (Z)-1 can be photoisomerized to (E)-1 under room light in CDCl3. The product (Z)-1 was obtained by a four-component coupling reaction of 4-iodotoluene, phenylacetylene, KCN, and carbon monoxide. A new synthesis of tetrasubstituted furans is also mentioned.