253679-32-2Relevant articles and documents
Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design
Mori, Matteo,Stelitano, Giovanni,Gelain, Arianna,Pini, Elena,Chiarelli, Laurent R.,Sammartino, José C.,Poli, Giulio,Tuccinardi, Tiziano,Beretta, Giangiacomo,Porta, Alessio,Bellinzoni, Marco,Villa, Stefania,Meneghetti, Fiorella
, p. 7066 - 7080 (2020/07/28)
The Mg2+-dependent Mycobacterium tuberculosis salicylate synthase (MbtI) is a key enzyme involved in the biosynthesis of siderophores. Because iron is essential for the survival and pathogenicity of the microorganism, this protein constitutes an attractiv
Discovery of new C3aR ligands. Part 1: Arginine derivatives
Denonne, Frederic,Binet, Sophie,Burton, Maggi,Collart, Philippe,Dipesa, Alan,Ganguly, Tanmoy,Giannaras, Alexander,Kumar, Seema,Lewis, Timothy,Maounis, Florence,Nicolas, Jean-Marie,Mansley, Tamsin,Pasau, Patrick,Preda, Dorin,Stebbins, Karin,Volosov, Alexander,Zou, Dong
, p. 3258 - 3261 (2008/02/08)
The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inflamma