25368-09-6

Basic information

• Product Name: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
• Synonyms: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
• CAS NO: 25368-09-6
• Molecular Formula: C21H26O4
• Molecular Weight: 342.42874
• Mol File: 25368-09-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester(25368-09-6)
• EPA Substance Registry System: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester(25368-09-6)

Safety Data

• Hazardous Substances Data: 25368-09-6(Hazardous Substances Data)

Usage

General Description

8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester is a chemical compound used in the field of organic synthesis and chemical research. It is a carotenoid derivative, which means it belongs to a class of organic compounds that are responsible for the color in fruits and vegetables. This specific compound is a methyl ester of 8,8'-diapo-ψ,ψ-carotene-8,8'-dioic acid, and it has potential applications in the food and pharmaceutical industries. Its structure allows it to act as an antioxidant, protecting cells from damage caused by harmful molecules known as free radicals. Additionally, it could play a role in medical research, particularly in the development of new drugs and therapies for various health conditions.

Upstream product

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Relevant articles and documents

Natural apocarotenoids and their synthetic glycopeptide conjugates inhibit sars-cov-2 replication

The protracted global COVID-19 pandemic urges the development of new drugs against the causative agent SARS-CoV-2. The clinically used glycopeptide antibiotic, teicoplanin, emerged as a potential antiviral, and its efficacy was improved with lipophilic modifications. This prompted us to prepare new lipophilic apocarotenoid conjugates of teicoplanin, its pseudoaglycone and the related ristocetin aglycone. Their antiviral effect was tested against SARS-CoV-2 in Vero E6 cells, using a cell viability assay and quantitative PCR of the viral RNA, confirming their micromolar inhibitory activity against viral replication. Interestingly, two of the parent apocarotenoids, bixin and β-apo-8’carotenoic acid, exerted remarkable anti-SARS-CoV-2 activity. Mechanistic studies involved cathepsin L and B, as well as the main protease 3CLPro, and the results were rationalized by computational studies. Glycopeptide conjugates show dual inhibitory action, while apocarotenoids have mostly cathepsin B and L affinity. Since teicoplanin is a marketed antibiotic and the natural bixin is an approved, cheap and widely used red colorant food additive, these readily available compounds and their conjugates as potential antivirals are worthy of further exploration.