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25371-96-4

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25371-96-4 Usage

Description

TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2

Uses

TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

References

1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423

Check Digit Verification of cas no

The CAS Registry Mumber 25371-96-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,3,7 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25371-96:
(7*2)+(6*5)+(5*3)+(4*7)+(3*1)+(2*9)+(1*6)=114
114 % 10 = 4
So 25371-96-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-2-1-3-9(6-8)15-5-4-14-7-15/h1-7H

25371-96-4 Well-known Company Product Price

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  • TCI America

  • (T2982)  1-[2-(Trifluoromethyl)phenyl]imidazole  >98.0%(GC)

  • 25371-96-4

  • 1g

  • 995.00CNY

  • Detail
  • Alfa Aesar

  • (L10465)  1-(2-Trifluoromethylphenyl)imidazole, 98+%   

  • 25371-96-4

  • 1g

  • 669.0CNY

  • Detail

25371-96-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-(trifluoromethyl)phenyl]imidazole

1.2 Other means of identification

Product number -
Other names 1-[2-(Trifluoromethyl)phenyl]imidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25371-96-4 SDS

25371-96-4Downstream Products

25371-96-4Relevant articles and documents

Cu-Al hydrotalcite: An efficient and reusable ligand-free catalyst for the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines

Sreedhar,Arundhathi,Linga Reddy,Amarnath Reddy,Lakshmi Kantam

experimental part, p. 2517 - 2522 (2010/03/24)

Copper-aluminum hydrotalcite catalysts were effectively used in the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines to afford the corresponding N-alkylated/arylated amines in excellent yields. The catalyst was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity. Georg Thieme Verlag Stuttgart.

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