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25373-69-7

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25373-69-7 Usage

General Description

2,6-Dibromopyridine oxide is a chemical compound with the molecular formula C5H3Br2NO. It exists as a colorless solid and is primarily used as an intermediate in the manufacturing of pharmaceuticals and agrochemicals. It is a highly reactive compound and can undergo various chemical reactions, including nucleophilic substitution and oxidation. 2,6-Dibromopyridine oxide is also known for its potential use as a building block in organic synthesis and for its ability to form coordination complexes with metal ions. It is important to handle this compound with care as it may pose health and environmental risks due to its reactivity and potential toxicity.

Check Digit Verification of cas no

The CAS Registry Mumber 25373-69-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,3,7 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25373-69:
(7*2)+(6*5)+(5*3)+(4*7)+(3*3)+(2*6)+(1*9)=117
117 % 10 = 7
So 25373-69-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H3Br2NO/c6-4-2-1-3-5(7)8(4)9/h1-3H

25373-69-7 Well-known Company Product Price

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  • Aldrich

  • (745960)  2,6-Dibromopyridine N-oxide  

  • 25373-69-7

  • 745960-5G

  • 473.85CNY

  • Detail
  • Aldrich

  • (745960)  2,6-Dibromopyridine N-oxide  

  • 25373-69-7

  • 745960-25G

  • 2,158.65CNY

  • Detail

25373-69-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-dibromo-1-oxidopyridin-1-ium

1.2 Other means of identification

Product number -
Other names 2,6-dibromopyridin-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25373-69-7 SDS

25373-69-7Relevant articles and documents

A strong hydride donating, acid stable and reusable 1,4-dihydropyridine for selective aldimine and aldehyde reductions

Hirao, Yasukazu,Eto, Hajime,Teraoka, Mitsuru,Kubo, Takashi

supporting information, p. 1671 - 1679 (2022/03/02)

A 1,4-dihydropyridine derivative, lacking carbonyl groups and containing bulky aryl substituents, was synthesized and found to have a high hydride donating ability, acid resistance and reusability. Thermodynamic parameters for electron and hydride transfer in the redox system comprising the 1,4-dihydropyridine and its corresponding pyridinium ion were determined. In addition, studies showed that the 1,4-dihydropyridine with steric hindrance can be used to promote efficient, boron trifluoride catalyzed selective reduction reactions of aldimines and aldehydes under mild conditions.

Interaction of the dihydropyridine/pyridinium redox pair fixed into a V-shaped conformation

Hirao, Yasukazu,Teraoka, Mitsuru,Kubo, Takashi

, p. 1345 - 1353 (2019/12/23)

A new V-shaped molecule incorporating a dihydropyridine and a pyridinium moiety was synthesized and evaluated for its effect on the interaction between the hydride donor-acceptor pair. Spectroscopic, electrochemical, and computational studies have revealed the presence of the charge transfer interaction as a consequence of the electron donor-acceptor association.

Inhibition of cancer-associated mutant isocitrate dehydrogenases: Synthesis, structure-activity relationship, and selective antitumor activity

Liu, Zhen,Yao, Yuan,Kogiso, Mari,Zheng, Baisong,Deng, Lisheng,Qiu, Jihui J.,Dong, Shuo,Lv, Hua,Gallo, James M.,Li, Xiao-Nan,Song, Yongcheng

supporting information, p. 8307 - 8318 (2014/12/11)

Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant enzymes catalyze the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric acid (D2HG), leading to cancer initiation. Several 1-hydroxypyridin-2-one compounds were identified to be inhibitors of IDH1(R132H). A total of 61 derivatives were synthesized, and their structure-activity relationships were investigated. Potent IDH1(R132H) inhibitors were identified with Ki values as low as 140 nM, while they possess weak or no activity against WT IDH1. Activities of selected compounds against IDH1(R132C) were found to be correlated with their inhibitory activities against IDH1(R132H), as well as cellular production of D2HG, with R2 of 0.83 and 0.73, respectively. Several inhibitors were found to be permeable through the blood-brain barrier in a cell-based model assay and exhibit potent and selective activity (EC50 = 0.26-1.8 μM) against glioma cells with the IDH1 R132H mutation.

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